Regulatory roles of RNA modifications in breast cancer.
Regulatory roles of RNA modifications in breast cancer.
复制标题
DOI：
10.1093/narcan/zcab036
复制
发表时间：
2021-09
期刊：
影响因子：
5.1
通讯作者：
Aguilo F
中科院分区：
文献类型：
--
作者：
Kumari K;Groza P;Aguilo F
RNA修饰统称为表转录组，在基因表达调控相关细胞过程中发挥重要作用。在过去的几十年里，越来越多的RNA修饰不仅在丰富的核糖体（rRNA）和转运RNA（tRNA）中被发现，而且在信使RNA（mRNA）中也被发现。此外，许多动态调节化学标记的写入器、擦除器和读取器也被表征。RNA修饰的正确沉积是细胞内稳态的先决条件，并且其改变导致异常转录程序，其决定人类疾病，包括乳腺癌，最常见的女性恶性肿瘤，以及女性癌症相关死亡的主要原因。在这篇综述中，我们强调了主要的RNA修饰存在于tRNA，rRNA和mRNA。我们对乳腺癌相关的化学标志物进行了分类，并总结了它们对乳腺肿瘤发生的贡献。此外，我们还描述了与乳腺癌有关的相关通路的不太丰富的tRNA修饰。最后，我们讨论了目前的局限性和前景epitranscriptomics用于治疗乳腺癌和其他癌症的策略。乳腺癌中已知的RNA修饰。
Collectively referred to as the epitranscriptome, RNA modifications play important roles in gene expression control regulating relevant cellular processes. In the last few decades, growing numbers of RNA modifications have been identified not only in abundant ribosomal (rRNA) and transfer RNA (tRNA) but also in messenger RNA (mRNA). In addition, many writers, erasers and readers that dynamically regulate the chemical marks have also been characterized. Correct deposition of RNA modifications is prerequisite for cellular homeostasis, and its alteration results in aberrant transcriptional programs that dictate human disease, including breast cancer, the most frequent female malignancy, and the leading cause of cancer-related death in women. In this review, we emphasize the major RNA modifications that are present in tRNA, rRNA and mRNA. We have categorized breast cancer-associated chemical marks and summarize their contribution to breast tumorigenesis. In addition, we describe less abundant tRNA modifications with related pathways implicated in breast cancer. Finally, we discuss current limitations and perspectives on epitranscriptomics for use in therapeutic strategies against breast and other cancers. Modifications of RNA known in breast cancer.