Psychoneuroimmunology and cancer: Fact or fiction?
Psychoneuroimmunology and cancer: Fact or fiction?
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DOI：
10.1016/s0959-8049(99)00197-5
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发表时间：
1999-10-01
影响因子：
8.4
通讯作者：
Glaser, R
中科院分区：
文献类型：
--
作者：
Kiecolt-Glaser, JK;Glaser, R
这两个健康人群也有大量证据。将心理压力与免疫下调联系起来的癌症患者。本讨论强调了自然杀伤（NK）细胞，因为它们可能在恶性疾病中发挥作用。此外，痛苦或抑郁也与两个重要的致癌过程有关：受损DNA的修复较差，以及细胞凋亡的改变。相反，心理干预可能增强癌症患者的免疫功能和生存率的可能性显然值得进一步探索，因为有证据表明社会支持可能是一个关键的心理中介。这些研究和其他研究表明，心理或行为因素可能通过对免疫功能和其他生理途径的心理社会影响来影响癌症的发病率或进展。(C)1999爱思唯尔科技有限公司。保留所有权利。
There is substantial evidence from both healthy populations as well. as individuals with cancer linking psychological stress with immune downregulation. This discussion highlights natural killer (NK) cells, because of the role that they may play in malignant disease. In addition, distress or depression is also associated with two important processes for carcinogenesis: poorer repair of damaged DNA, and alterations in apoptosis. Conversely, the possibility that psychological interventions may enhance immune function and survival among cancer patients clearly merits further exploration, as does the evidence suggesting that social support may be a key psychological mediator. These studies and others suggest that psychological or behavioural factors may influence the incidence or progression of cancer through psychosocial influences on immune function and other physiological pathways. (C) 1999 Elsevier Science Ltd. All rights reserved.