Epithelial cell innate response to Candida albicans.
Epithelial cell innate response to Candida albicans.
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DOI：
10.1177/0022034511399285
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发表时间：
2011-04-01
影响因子：
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通讯作者：
Moyes, D
中科院分区：
文献类型：
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作者：
Naglik, J R;Moyes, D
随着治疗和疾病如艾滋病的出现，导致越来越多的患者免疫系统受到抑制，真菌疾病是一个不断升级的问题。白色念珠菌是这些真菌病原体中最常见的，导致许多患者感染。因此，了解对这种真菌的免疫力是如何调节的以及如何操纵它是很重要的。虽然已经做了工作，以确定受体，真菌部分，并参与抗念珠菌免疫的反应，大多数研究调查与骨髓或淋巴细胞的相互作用。鉴于C.白念珠菌与其宿主是粘膜上皮表面，近年来的研究开始关注白念珠菌与粘膜上皮表面的相互作用。白色的这个网站。结果令人吃惊，但回顾起来是显而易见的，表明上皮细胞在这些相互作用中起着重要作用，启动反应，甚至提供一定程度的保护。这些发现不仅对真菌病原体有明显的意义，而且对确定宿主生物如何区分真菌和病原微生物也有明显的意义。这篇综述强调了其中一些最新的发现，并讨论了它们在更广泛的感染和免疫背景下的重要性。
With the advent of treatments and diseases such as AIDS resulting in increasing numbers of patients with suppressed immune systems, fungal diseases are an escalating problem. Candida albicans is the most common of these fungal pathogens, causing infections in many of these patients. It is therefore important to understand how immunity to this fungus is regulated and how it might be manipulated. Although work has been done to identify the receptors, fungal moieties, and responses involved in anti-Candida immunity, most studies have investigated interactions with myeloid or lymphoid cells. Given that the first site of contact of C. albicans with its host is the mucosal epithelial surface, recent studies have begun to focus on interactions of C. albicans with this site. The results are startling yet in retrospect obvious, indicating that epithelial cells play an important role in these interactions, initiating responses and even providing a level of protection. These findings have obvious implications, not just for fungal pathogens, but also for identifying how host organisms can distinguish between commensal and pathogenic microbes. This review highlights some of these recent findings and discusses their importance in the wider context of infection and immunity.