Association of LRRK2 R1628P variant with Parkinson's disease in Ethnic Han-Chinese and subgroup population.
Association of LRRK2 R1628P variant with Parkinson's disease in Ethnic Han-Chinese and subgroup population.
复制标题
汉族及其亚群人群LRRK2 R1628P变异与帕金森病的相关性
DOI：
10.1038/srep35171
复制
发表时间：
2016-11-04
影响因子：
4.6
通讯作者：
Tian B
中科院分区：
文献类型：
--
作者：
Zhang P;Wang Q;Jiao F;Yan J;Chen L;He F;Zhang Q;Tian B
最近的研究表明，富含亮氨酸重复序列激酶2（LRRK2）基因的某些单核苷酸多态性与帕金森病（PD）有关。LRRK2的R1628P变异可能是中国汉族人群中PD的一个特异性危险因素。本研究旨在阐明R1628 P在汉族PD人群中的流行病学特征。进行了一项全面的荟萃分析，以评估R1628 P变异与中国汉族和按性别、发病年龄或家族史分层的亚组中PD风险之间的精确关联。评估R1628P对汉族PD风险作用的分析支持显著相关性，比值比为1.86。我们进一步估计了相关汉族亚组的具体患病率。按性别、发病年龄或家族史分层后，在所有男性、女性、早发、晚发、家族性和散发亚组中均发现了显著相关性，比值比分别为1.90、1.94、2.12、1.75、6.71和1.81。总之，我们的荟萃分析表明，LRRK2的R1628P变异与中国汉族和亚组人群中PD的风险有显着关联。
Recent studies have linked certain single nucleotide polymorphisms in the leucine-rich repeat kinase 2 (LRRK2) gene with Parkinson’s disease (PD). The R1628P variant of LRRK2 may be a specific risk factor for PD in ethnic Han-Chinese populations. This study is to elucidate the epidemiological feature of R1628P in ethnic Han-Chinese population with PD. A comprehensive meta-analysis was performed to evaluate the precise association between R1628P variant and the risk for PD in ethnic Han-Chinese and subgroups stratified by gender, onset age, or family history. The analysis assessing the role of R1628P on the risk of PD in ethnic Han-Chinese supported a significant association, and the odds ratio was 1.86. We further estimate the specific prevalence in relevant ethnic Han-Chinese subgroups. After stratifying the eligible data by gender, onset age, or family history, significant associations were found in all male, female, early-onset, late-onset, familial and sporadic subgroups, and the odds ratio were 1.90, 1.94, 2.12, 1.75, 6.71 and 1.81 respectively. In conclusion, our meta-analysis suggests that R1628P variant of LRRK2 has a significant association with the risk of PD in ethnic Han-Chinese and subgroup population.
登录
查看更多内容
PhosSNP 用于系统分析影响蛋白质磷酸化的遗传多态性
影响因子：
7
作者：
Ren, Jian;Jiang, Chunhui;Yao, Xuebiao
通讯作者：
Yao, Xuebiao
影响因子：
8.6
作者：
Fung, Hon-Chung;Chen, Chiung-Mei;Wu, Yih-Ru
通讯作者：
Wu, Yih-Ru
影响因子：
2.9
作者：
Yu, Lihua;Hu, Fayun;Xu, Yanming
通讯作者：
Xu, Yanming
影响因子：
4.1
作者：
Farrer, Matthew J.;Stone, Jeremy T.;Wu, Ruey-Meei
通讯作者：
Wu, Ruey-Meei
影响因子：
8.6
作者：
Tomiyama, Hiroyuki;Li, Yuanzhe;Hattori, Nobutaka
通讯作者：
Hattori, Nobutaka