Estrogen replacement therapy moderates the sleep disruption associated with nocturnal blood sampling
Estrogen replacement therapy moderates the sleep disruption associated with nocturnal blood sampling
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DOI：
10.1093/sleep/24.8.886
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发表时间：
2001-12-15
期刊：
影响因子：
5.6
通讯作者：
Prinz, PN
中科院分区：
文献类型：
--
作者：
Moe, KE;Larsen, LH;Prinz, PN
研究目的：确定长期口服雌激素替代疗法(ERT)(1)是否能改善无症状的老年绝经后妇女的睡眠；(2)减少应激源(经常通过静脉导管远程采集夜间血液)对睡眠的干扰。设计：一项更大规模的研究的描述性、横断面、二次分析。地点：华盛顿大学医学中心综合临床研究中心。参与者：57-80岁(平均年龄=70岁)绝经后至少5年的女性来自社区。潮热和严重的睡眠困难是排除标准。ERT组(n=37)由长期口服ERT超过或等于2年的妇女组成。NERT组(n=56)包括超过或等于2年不使用雌激素(NERT)的妇女。干预：N/AM测量和结果：在适应之夜之后，连续2个晚上收集多导睡眠监测数据。在过去的24小时内(包括第二夜)，通过静脉导管每20分钟采集一次血样。NERT女性在基线(非导尿管)夜间睡眠的唯一差异是睡眠潜伏期较短。与基线相比，导尿管夜间睡眠的特点是觉醒增加，睡眠潜伏期延长，REM睡眠减少。然而，夜间采血对惰性女性的影响比ERT女性大得多：她们在更多睡眠觉醒变量，特别是慢波睡眠(SWS)方面经历了显著更大的百分比变化。结论：在这项横断面研究中，使用长期口服ERT对没有潮热症状的老年女性睡眠几乎没有影响，除非存在睡眠挑战。ERT改善了夜间采血对客观评估和主观评估睡眠的干扰作用。
Study Objectives: To determine whether chronic oral estrogen replacement therapy (ERT) (1) improves the sleep of older, non-symptomatic postmenopausal women; and (2) reduces the sleep disruption associated with a stressor (frequent remote nocturnal blood-sampling through an intravenous catheter).Design: Descriptive, cross-sectional, secondary analysis of a larger study.Setting: The General Clinical Research Center at the University of Washington Medical Center.Participants: Women aged 57-80 (mean age = 70) at least 5 years past menopause were recruited from the community. Hot flashes and significant sleep difficulties were exclusion criteria. The ERT group (n=37) consisted of women on chronic oral ERT for greater than or equal to2 years. The NERT group (n=56) consisted of women not using estrogen (NERT) for greater than or equal to2 years.Interventions: N/AMeasurements and Results: Following an adaptation night, polysomnographic measures were collected for 2 consecutive nights. A blood sample was collected every 20 minutes for the last 24 hours (including Night 2), through an intravenous catheter. The only group difference in sleep on the baseline (non-catheter) night was that NERT women had a shorter sleep latency. Sleep on the catheter night was characterized by increased wakefulness, longer sleep latency, and decreased REM sleep for both groups relative to the baseline. However, the impact of nocturnal blood sampling was much greater for INERT than for ERT women: they experienced significantly greater percent changes in more sleep-wake variables, particularly slow-wave sleep (SWS).Conclusions: In this cross-sectional study, the use of chronic oral ERT was associated with little effect on the sleep of older postmenopausal women not experiencing hot flashes, except in the presence of a challenge to sleep. ERT ameliorated the disruptive effect of nocturnal blood sampling on both objectively assessed and subjectively assessed sleep.