Silver Carboxylate as an Antibiotic-Independent Antimicrobial: A Review of Current Formulations, in vitro Efficacy, and Clinical Relevance.
Silver Carboxylate as an Antibiotic-Independent Antimicrobial: A Review of Current Formulations, in vitro Efficacy, and Clinical Relevance.
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DOI：
10.18103/mra.v10i12.3388
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发表时间：
2022-12
期刊：
影响因子：
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通讯作者：
Garcia, Dioscaris R
中科院分区：
文献类型：
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作者：
Mette, Makena;Connolly, William;Vishwanath, Neel;Allu, Sai;Whitaker, Colin;Stone, Benjamin K;Antoci, Valentin;Born, Christopher T;Garcia, Dioscaris R
随着多重耐药病原体的日益流行，银作为一种不依赖抗生素的抗菌剂的使用再次受到关注。不幸的是，许多银制剂的使用可能受到银的不受控制的释放的限制，这可能会产生显著的细胞毒性作用。羧酸银(AgCar)已作为银的替代配方出现，具有缓解这些担忧的潜力，同时仍显示出显著的杀菌活性。本文综述了羧酸银制剂作为一种有前途的新型抗生素非依赖性抗菌剂的疗效。这项研究是通过搜索五个电子数据库(PubMed、Embase、MEDLINE、Cochrane图书馆和Web of Science)进行的，以获取截至2022年9月的相关研究。搜索“羧酸银”配方的类型。资料来源根据标题和摘要进行汇编，并根据相关性和研究设计进行筛选。在此基础上，对羧酸银的抗菌活性和细胞毒性进行了综述。目前的大量数据表明，羧酸银作为一种新兴的抗生素非依赖性抗菌剂前景看好，具有显著的杀菌效果，同时将细胞毒性降至最低。羧酸银解决了更原始配方的几个限制，包括受控剂量和对真核细胞系的较少负面影响。这些因素依赖于集中度，并在很大程度上取决于交付它的车辆系统。尽管几种基于羧酸银的制剂，如二氧化钛/聚二甲基硅氧烷(二氧化钛/聚二甲基硅氧烷)基质洗脱AgCar在体外显示出良好的结果，并有可能单独使用或与当前和未来的抗菌治疗一起使用，但仍需要进一步的体内研究来验证其总体安全性和有效性。
The increasing prevalence of multi-drug resistant pathogens has led to a renewed focus on the use of silver as an antibiotic-independent antimicrobial. Unfortunately, the use of many silver formulations may be limited by an uncontrolled release of silver with the potential for significant cytotoxic effects. Silver carboxylate (AgCar) has emerged as an alternative formulation of silver with the potential to mitigate these concerns while still displaying significant bactericidal activity. This article reviews the efficacy of silver carboxylate formulations as a promising novel antibiotic-independent antimicrobial. This study was conducted through a search of five electronic databases (PubMed, Embase, MEDLINE, Cochrane Library, and Web of Science) for relevant studies up to September 2022. Searches were conducted for types of “silver carboxylate” formulations. Sources were compiled based on title and abstract and screened for inclusion based on relevance and study design. A review of the antimicrobial activity and cytotoxicity of silver carboxylate was compiled based on this search. Current body of data suggests that silver carboxylate shows promise as an emerging antibiotic-independent antimicrobial, with significant bactericidal effects while minimizing cytotoxicity. Silver carboxylate addresses several of the limitations of more primitive formulations, including controlled dosing and fewer negative effects on eukaryotic cell lines. These factors are concentration-dependent and largely rely on the vehicle system used to deliver it. Although several silver carboxylate-based formulations like titanium dioxide/polydimethylsiloxane (TiO2/PDMS) matrix-eluting AgCar have shown promising results in vitro, and could potentially be utilized independently or in conjunction with current and future antimicrobial therapies, there is a need for further in vivo studies to validate their overall safety and efficacy profile.