The Pontomedullary Reticular Formation Contributes to the Compensatory Postural Responses Observed Following Removal of the Support Surface in the Standing Cat
The Pontomedullary Reticular Formation Contributes to the Compensatory Postural Responses Observed Following Removal of the Support Surface in the Standing Cat
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DOI：
10.1152/jn.91013.2008
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发表时间：
2009-03-01
影响因子：
2.5
通讯作者：
Drew, Trevor
中科院分区：
文献类型：
--
作者：
Stapley, Paul J.;Drew, Trevor
Stapley PJ，Drew T.桥延髓网状结构有助于在移除站立猫的支撑面后观察到的代偿姿势反应。神经生理学杂志101：1334-1350,2009。2008年12月31日首次出版；DOI：10.1152/jn.91013.2008。本研究旨在确定脑桥延髓网状结构(PMRF)中网状神经元对产生的姿势反应的贡献，以补偿意外的干扰。我们记录了4只猫的PMRF中48个神经元的活动，其中包括41个网状脊髓神经元，以去除四肢下方的支撑面。这些扰动产生了强健的姿势反应，分为三个阶段：初始姿势反应(P1)，使两个对角支撑肢体的垂直压力中心移位；二级反应(P2)，在此期间猫恢复了三足支撑模式；以及延长的第三反应(P3)，在所有三个支撑肢体上保持稳定的姿势。大多数(44/48)网状神经元对至少一个肢体的扰动表现出修饰的活动，大多数(39/48)对多个肢体的扰动表现出活动的变化。少数患者(7/48)因四肢功能紊乱而出院。在P_1期间，表现为活动增加的神经元的放电频率相对较高(57%的神经元对左或右前肢LF1和RFL的扰动有反应)，并且潜伏期短(LFL为17ms，RFL为14ms)。大多数神经元的放电活动在整个P2和P3中持续存在，但水平有所降低。这些数据表明，PMRF中的神经元对意想不到的干扰做出强烈反应，并以与恢复平衡的代偿反应相一致的方式进行强烈放电。
Stapley PJ, Drew T. The pontomedullary reticular formation contributes to the compensatory postural responses observed following removal of the support surface in the standing cat. J Neurophysiol 101: 1334-1350, 2009. First published December 31, 2008; doi:10.1152/jn.91013.2008. This study was designed to determine the contribution of reticular neurons in the pontomedullary reticular formation (PMRF) to the postural responses produced to compensate for an unexpected perturbation. We recorded the activity of 48 neurons in the PMRF, including 41 reticulospinal neurons, to removal of the support surface under each of the four limbs in four cats. The perturbations produced robust postural responses that were divided into three periods: an initial postural response (P1) that displaced the center of vertical pressure over the two diagonal supporting limbs; a secondary response (P2) during which the cat restored a tripedal support pattern; and a prolonged tertiary response (P3) that maintained a stable posture over all three supporting limbs. Most (44/48) reticular neurons showed modified activity to perturbation of at least one limb and a majority (39/48) showed changes in activity to perturbations of more than one limb. A few (7/48) discharged to perturbations of all four limbs. Discharge frequency in neurons showing increased activity during P1 was relatively high (> 100 Hz in 57% of the neurons responding to perturbations of either the left or right forelimbs, lF1 and rFL) and of short latency (17 ms for the lFL and 14 ms for the rFL). Discharge activity in most neurons was sustained throughout P2 and P3 but at a reduced level. These data show that neurons in the PMRF discharge strongly in response to unexpected perturbations and in a manner consistent with a contribution to the compensatory responses that restore equilibrium.