Candida glabrata colonizes but does not often disseminate from the mouse caecum.
Candida glabrata colonizes but does not often disseminate from the mouse caecum.
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光滑念珠菌在小鼠盲肠中定殖，但并不经常传播。
DOI：
10.1099/jmm.0.47049-0
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发表时间：
2007
影响因子：
3
通讯作者：
Bendel,CatherineM
中科院分区：
文献类型：
--
作者：
Wells,CarolL;Johnson,Mary-Alice;Henry-Stanley,MichelleJ;Bendel,CatherineM
光滑念珠菌是念珠菌血症的第二或第三常见原因。胃肠道被认为是系统性念珠菌病的主要入口，但相对较少的研究探讨了念珠菌病的发病机制。光滑的设计实验来阐明C.从小鼠肠道传播。经口接种后，C. glabratareadily殖民盲肠[约。107个细胞（g盲肠）-1]，但未检测到肠外播散。叠加几种已知可诱导白色念珠菌和其他肠道微生物传播的创伤和/或免疫抑制小鼠模型，不会导致C.尽管给予高剂量地塞米松4天的小鼠是一个例外，但是，这些数据支持这一假设，即驱虫处理的小鼠肠道可能是一个流行病学水库为C。glabrata和这种酵母菌往往传播在特定的临床条件下。
Candida glabratais the second or third most frequent cause of candidaemia. The gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis ofC. glabrata. Experiments were designed to clarify the ability ofC. glabratato disseminate from the mouse intestinal tract. Following oral inoculation,C. glabratareadily colonized the caeca [approx. 107cells (g caecum)−1] of antibiotic-treated mice, but extraintestinal dissemination was not detected. Superimposing several mouse models of trauma and/or immunosuppression known to induce dissemination ofCandida albicansand other intestinal microbes did not causeC. glabratato disseminate often, although one exception was mice given high doses of dexamethasone for 4 days. These data support the hypothesis that the antibiotic-treated mouse intestine may be an epidemiological reservoir forC. glabrataand that this yeast tends to disseminate under specific clinical conditions.