Homeostasis of peripheral immune effectors.
Homeostasis of peripheral immune effectors.
复制标题
外周免疫效应器的稳态。
DOI：
10.1016/j.bulm.2004.02.003
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Segel,Lee
中科院分区：
文献类型：
--
作者：
Warrender,Christina;Forrest,Stephanie;Segel,Lee
在本文中，我们使用数学建模和模拟来探索外周免疫系统效应细胞，特别是肺泡巨噬细胞的稳态。我们的兴趣是在分布式控制机制，使这样的人口，以保持自己。我们介绍了一个多用途的模拟器，旨在研究个别细胞的反应，当地的分子信号及其对人口动态的影响。我们使用模拟器来开发生长因子调节巨噬细胞增殖和存活的模型。我们研究的影响，这种形式的监管的上下文中的两个竞争的假设，新的肺泡巨噬细胞的来源。在一个模型中，局部细胞分裂以补充种群;在另一个模型中，只有从循环迁移的细胞分裂。我们发现，这两种情况都是合理的，虽然流入驱动系统本质上更稳定。增殖驱动系统需要比流入驱动系统更低的细胞死亡率和流出率。
In this paper, we use both mathematical modeling and simulation to explore homeostasis of peripheral immune system effector cells, particularly alveolar macrophages. Our interest is in the distributed control mechanisms that allow such a population to maintain itself. We introduce a multi-purpose simulator designed to study individual cell responses to local molecular signals and their effects on population dynamics. We use the simulator to develop a model of growth factor regulation of macrophage proliferation and survival. We examine the effects of this form of regulation in the context of two competing hypotheses regarding the source of new alveolar macrophages. In one model, local cells divide to replenish the population; in the other, only cells migrating from circulation divide. We find that either scenario is plausible, although the influx-driven system is inherently more stable. The proliferation-driven system requires lower cell death and efflux rates than the influx-driven system.