New strategy for monitoring targeted therapy: molecular imaging.
New strategy for monitoring targeted therapy: molecular imaging.
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监测靶向治疗的新策略：分子成像
DOI：
10.2147/ijn.s51264
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发表时间：
2013
影响因子：
8
通讯作者：
Yu JM
中科院分区：
文献类型：
--
作者：
Teng FF;Meng X;Sun XD;Yu JM
靶向治疗正在成为癌症治疗中越来越重要的组成部分。如何准确地监测靶向治疗已成为临床实践中的关键问题。通过成像监测治疗的传统方法依赖于根据世界卫生组织的改进标准评估肿瘤大小的变化，或者最近通过实体肿瘤反应评估标准。然而，这些基于肿瘤大小变化的标准在评估靶向治疗方面存在一定的局限性。目前，基因改变被确定为与预后和预测潜力有关的分子靶向药物的使用。相反，考虑到侵袭性的局限性和表达异质性的问题，分子成像能够更好地无创和定量地分析体内生物过程，并且已经成为临床癌症实践中监测治疗的特别有吸引力的工具。本文综述了基于正电子发射层析成像、磁共振成像、超声成像和计算机层析成像等不同类型分子成像技术在监测靶向治疗中的应用。此外，解决了分子成像的关键挑战，以便在未来成功地转化这些有前途的技术。
Targeted therapy is becoming an increasingly important component in the treatment of cancer. How to accurately monitor targeted therapy has been crucial in clinical practice. The traditional approach to monitor treatment through imaging has relied on assessing the change of tumor size by refined World Health Organization criteria, or more recently, by the Response Evaluation Criteria in Solid Tumors. However, these criteria, which are based on the change of tumor size, show some limitations for evaluating targeted therapy. Currently, genetic alterations are identified with prognostic as well as predictive potential concerning the use of molecularly targeted drugs. Conversely, considering the limitations of invasiveness and the issue of expression heterogeneity, molecular imaging is better able to assay in vivo biologic processes noninvasively and quantitatively, and has been a particularly attractive tool for monitoring treatment in clinical cancer practice. This review focuses on the applications of different kinds of molecular imaging including positron emission tomography-, magnetic resonance imaging-, ultrasonography-, and computed tomography-based imaging strategies on monitoring targeted therapy. In addition, the key challenges of molecular imaging are addressed to successfully translate these promising techniques in the future.