Association between Neurotrophin-3 Polymorphisms and Executive Function in Japanese Patients with Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease
Association between Neurotrophin-3 Polymorphisms and Executive Function in Japanese Patients with Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease
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DOI：
10.1159/000343075
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发表时间：
2012-10
影响因子：
2.4
通讯作者：
Nobuyuki Kobayashi;T. Nagata;Shunichiro Shinagawa;Ritsuko Nakayama;K. Kondo;K. Nakayama;Hisashi Yamada-Hisashi-Yama
中科院分区：
文献类型：
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作者：
Nobuyuki Kobayashi;T. Nagata;Shunichiro Shinagawa;Ritsuko Nakayama;K. Kondo;K. Nakayama;Hisashi Yamada-Hisashi-Yama
背景：我们研究了神经营养素(NT)-3基因多态性是否会影响两种不同疾病阶段的痴呆患者的执行功能：遗忘性轻度认知障碍(A-MCI)或轻度阿尔茨海默病(AD)。方法：在215例门诊痴呆和MCI患者中，155例轻度AD患者(n=108)和A-MCI患者(n=47)根据代表的NT-3功能多态rs6332和rs6489630分为3组。接下来，我们比较了三个基因型组之间的额叶评估成套测验(FAB)总分和分测验分数。结果：FAB总分与rs6332和rs6489630等位基因无显著相关，但6个分测验间的指令冲突得分与rs6332基因显著相关(p<；0.05)。此外，在轻度AD患者中，rs6332的三个等位基因组间的指令冲突得分差异有统计学意义(G/G<；A/A：P=0.042和G/A<；A/A：P=0.041)。Rs6332和rs6489630三种基因在其他人口学变量上均无显著差异。结论：NT-3基因rs6332多态性可能显著影响执行功能，反映轻度AD患者的干预行为。
Background: We investigated whether neurotrophin (NT)-3 polymorphisms influenced the executive function of patients with 2 separate disease stages with similar dementia conditions: amnestic mild cognitive impairment (A-MCI) or mild Alzheimer disease (AD). Methods: Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630. Next, we compared the frontal assessment battery (FAB) total and subtest scores between the three genotypic groups. Results: The total FAB score was not significantly associated with the rs6332 and rs6489630 genotypes; however, the conflicting instructions score among the 6 subtests was significantly associated with the rs6332 genotype (p < 0.05). Moreover, in patients with mild AD, the conflicting instructions score differed significantly among the three genotypic groups of rs6332 (p < 0.05) (G/G < A/A: p = 0.042 and G/A < A/A: p = 0.041). No significant differences in any other demographic variables were observed among the three genotypes of rs6332 and rs6489630. Conclusion: These results suggested that an NT-3 polymorphism, rs6332, may significantly influence executive function, reflecting interference performances among patients with mild-stage AD.