Regional myocardial function after repetitive brief episodes of ischemia: effect of altering the duration of the reperfusion period.
Regional myocardial function after repetitive brief episodes of ischemia: effect of altering the duration of the reperfusion period.
复制标题
重复短暂缺血发作后的局部心肌功能：改变再灌注期持续时间的影响。
DOI：
10.1016/0002-8703(91)90135-5
复制
发表时间：
1991
影响因子：
4.8
通讯作者：
Warltier,DC
中科院分区：
文献类型：
--
作者：
Wynsen,JC;Kenny,D;Brooks,HL;Warltier,DC
在长期使用仪器的清醒犬中，研究了反复短暂冠状动脉闭塞后再灌注持续时间的改变如何影响心肌局部收缩功能的恢复。所有动物均接受5次5分钟的左前降支冠状动脉闭塞，最后再灌注5小时。根据连续5分钟闭塞期之间的再灌注持续时间（5、10或15分钟）将犬随机分配至三组之一。闭塞之间的再灌注期的持续时间缩短导致多次闭塞-再灌注序列后收缩期缩短的恢复减少和进行性恶化。在15分钟的再灌注期内，第一至第四次再灌注期间的节段缩短百分比（%SS）范围为17.1 ± 2.6%至18.2 ± 1.8%，在最后一次再灌注期结束时与闭塞前对照值（18.8 ± 1.7%）无差异。相比之下，在具有5分钟再灌注期的那些犬中，在最终5小时再灌注期完成时（11.4 ± 1.5%），% SS从闭塞前对照值（20.2 ± 2.2%）显著降低。本研究的结果表明，只有几个短暂的冠状动脉闭塞后，快速和累积恶化的区域收缩功能时，间歇再灌注的持续时间是足够短的。
How recovery of regional contractile function in myocardium is influenced by alterations in the duration of reperfusion after repetitive brief coronary artery occlusions was investigated in chronically instrumented, conscious dogs. All animals underwent five 5 minute left anterior descending coronary artery occlusions with a final 5-hour reperfusion period. Dogs were randomly assigned to one of three groups determined by the duration of reperfusion (5, 10, or 15 minutes) between successive 5-minute occlusion periods. A shortening of the duration of the reperfusion period between occlusions led to reduced recovery and progressive deterioration in systolic shortening after multiple occlusion-reperfusion sequences. With 15-minute reperfusion periods, the percentage of segment shortening (%SS) during the first through fourth reperfusion periods ranged from 17.1 ± 2.6% to 18.2 ± 1.8% and did not differ from the preocclusion control value (18.8 ± 1.7%) by the end of the final reperfusion period. In contrast, in those dogs with 5-minute reperfusion periods, % SS was significantly reduced from the preocclusion control value (20.2 ± 2.2%) at the completion of the final 5-hour reperfusion period (11.4 ± 1.5%). Results of the present study indicate that after only a few brief periods of coronary artery occlusion, rapid and cumulative deterioration in regional contractile function can occur when the duration of intermittent reperfusion is sufficiently brief.