CerealsDB 3.0: expansion of resources and data integration.
CerealsDB 3.0: expansion of resources and data integration.
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CEATEALSDB 3.0：资源和数据集成的扩展。
DOI：
10.1186/s12859-016-1139-x
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发表时间：
2016-06-24
影响因子：
3
通讯作者：
Edwards KJ
中科院分区：
文献类型：
--
作者：
Wilkinson PA;Winfield MO;Barker GL;Tyrrell S;Bian X;Allen AM;Burridge A;Coghill JA;Waterfall C;Caccamo M;Davey RP;Edwards KJ
全球人口增长给资源带来压力，粮食安全成为21世纪的重要挑战。小麦（Triticum aestivum）是人类和牲畜饮食中最重要的作物之一，高产小麦品种的开发，加上对害虫的抵抗力和对气候变化的抵抗力的增强，意味着小麦育种已成为科学研究的重要焦点。为了促进小麦的这些改进，植物育种者利用分子工具来帮助他们识别重要农艺性状的基因，这些基因可以培育成新品种。现代分子技术确保了 SNP 标记的快速且廉价的表征以及现代基因分型方法的验证，产生了可用于标记辅助选择的宝贵资源。 CerealsDB 的创建是为了向全球育种者和研究人员快速传播这些信息。 CerealsDB 3.0 版是一个在线资源，包含广泛的小麦基因组数据集，将帮助植物育种家和科学家选择最合适的标记用于标记辅助选择。 CerealsDB 的数据库目前包含超过一百万个假定的品种 SNP，其中数十万个已经过实验验证。此外，CerealsDB 还包含有关功能性 SNP 的新数据，预计会对蛋白质功能产生重大影响，并且我们构建了一个网络服务来鼓励数据集成和高通量编程访问。 CerealsDB 是一个开放获取网站，其中包含对植物育种者和研究科学家有用的 SNP 信息。最近纳入了旨在联合基因组数据资源的网络服务，使 CerealsDB 上的信息能够与 WheatIS 网络和其他生物数据库更全面地集成。本文的在线版本 (doi:10.1186/s12859-016-1139-x) 包含补充材料，可供授权用户使用。
The increase in human populations around the world has put pressure on resources, and as a consequence food security has become an important challenge for the 21st century. Wheat (Triticum aestivum) is one of the most important crops in human and livestock diets, and the development of wheat varieties that produce higher yields, combined with increased resistance to pests and resilience to changes in climate, has meant that wheat breeding has become an important focus of scientific research. In an attempt to facilitate these improvements in wheat, plant breeders have employed molecular tools to help them identify genes for important agronomic traits that can be bred into new varieties. Modern molecular techniques have ensured that the rapid and inexpensive characterisation of SNP markers and their validation with modern genotyping methods has produced a valuable resource that can be used in marker assisted selection. CerealsDB was created as a means of quickly disseminating this information to breeders and researchers around the globe. CerealsDB version 3.0 is an online resource that contains a wide range of genomic datasets for wheat that will assist plant breeders and scientists to select the most appropriate markers for use in marker assisted selection. CerealsDB includes a database which currently contains in excess of a million putative varietal SNPs, of which several hundreds of thousands have been experimentally validated. In addition, CerealsDB also contains new data on functional SNPs predicted to have a major effect on protein function and we have constructed a web service to encourage data integration and high-throughput programmatic access. CerealsDB is an open access website that hosts information on SNPs that are considered useful for both plant breeders and research scientists. The recent inclusion of web services designed to federate genomic data resources allows the information on CerealsDB to be more fully integrated with the WheatIS network and other biological databases. The online version of this article (doi:10.1186/s12859-016-1139-x) contains supplementary material, which is available to authorized users.