ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis.
ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis.
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DOI：
10.1002/jlb.2mr0220-549r
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发表时间：
2020-09
影响因子：
5.5
通讯作者：
Sumagin R
中科院分区：
文献类型：
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作者：
Bui TM;Wiesolek HL;Sumagin R
ICAM-1是一种细胞表面糖蛋白和粘附受体，最为人所知的是调节白细胞从循环到炎症部位的募集。然而，除了血管内皮细胞，ICAM-1表达也强烈诱导上皮细胞和免疫细胞响应炎症刺激。重要的是，ICAM-1作为一种生物传感器，通过其胞质结构域与肌动蛋白细胞骨架的关联，在胞外结构域的配体接合后，来抑制外-内信号传导。因此，ICAM-1已成为在病理状态的开始和消退时许多基本细胞功能的主要调节剂。由于ICAM-1在驱动炎症反应中的作用已被广泛认可，本文将主要关注ICAM-1在上皮损伤-消退反应中的新出现的作用，以及炎症和肿瘤发生中的免疫细胞效应器功能。一段时间以来，ICAM-1一直具有临床和治疗意义;然而，抑制其功能以改善损伤消退的几次尝试都失败了。也许，更好地了解其在炎症消退中的有益作用或其在肿瘤发生中的新兴功能将引发重新审视ICAM-1作为潜在治疗靶点的临床价值的新兴趣。
ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly induced on epithelial and immune cells in response to inflammatory stimulation. Importantly, ICAM-1 serves as a biosensor to transduce outside-in-signaling via association of its cytoplasmic domain with the actin cytoskeleton following ligand engagement of the extracellular domain. Thus, ICAM-1 has emerged as a master regulator of many essential cellular functions both at the onset and at the resolution of pathologic conditions. Because the role of ICAM-1 in driving inflammatory responses is well recognized, this review will mainly focus on newly emerging roles of ICAM-1 in epithelial injury-resolution responses, as well as immune cell effector function in inflammation and tumorigenesis. ICAM-1 has been of clinical and therapeutic interest for some time now; however, several attempts at inhibiting its function to improve injury resolution have failed. Perhaps, better understanding of its beneficial roles in resolution of inflammation or its emerging function in tumorigenesis will spark new interest in revisiting the clinical value of ICAM-1 as a potential therapeutic target.
DOI：
10.1080/10739680902942271
发表时间：
2009-08
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
Sumagin R;Lamkin-Kennard KA;Sarelius IH
通讯作者：
Sarelius IH