Lidocaine Reduces Neutrophil Recruitment by Abolishing Chemokine-Induced Arrest and Transendothelial Migration in Septic Patients
Lidocaine Reduces Neutrophil Recruitment by Abolishing Chemokine-Induced Arrest and Transendothelial Migration in Septic Patients
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DOI：
10.4049/jimmunol.1301363
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Zarbock, Alexander
中科院分区：
文献类型：
--
作者：
Berger, Christian;Rossaint, Jan;Zarbock, Alexander
白细胞的不适当激活、定位和募集与脓毒症多器官衰竭的发病机制有关。虽然局部麻醉剂利多卡因调节炎症过程，但利多卡因在脓毒症中的作用仍然未知。这项双盲、前瞻性、随机临床试验旨在研究利多卡因对脓毒症患者白细胞募集的影响。14名脓毒症患者随机接受安慰剂（n = 7）或利多卡因（n = 7）推注（1.5 mg/kg），然后连续输注（>70 kg的患者为100 mg/h，>70 kg的患者为70 mg/h
The inappropriate activation, positioning, and recruitment of leukocytes are implicated in the pathogenesis of multiple organ failure in sepsis. Although the local anesthetic lidocaine modulates inflammatory processes, the effects of lidocaine in sepsis are still unknown. This double-blinded, prospective, randomized clinical trial was conducted to investigate the effect of lidocaine on leukocyte recruitment in septic patients. Fourteen septic patients were randomized to receive either a placebo (n = 7) or a lidocaine (n = 7) bolus (1.5 mg/kg), followed by continuous infusion (100 mg/h for patients >70 kg or 70 mg/h for patients