ANALOG STUDIES OF HUMAN SYSTEMIC ARTERIAL TREE
ANALOG STUDIES OF HUMAN SYSTEMIC ARTERIAL TREE
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DOI：
10.1016/0021-9290(69)90024-4
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发表时间：
1969-01-01
影响因子：
2.4
通讯作者：
NOORDERGRAAF, A
中科院分区：
文献类型：
--
作者：
WESTERHOF, N;BOSMAN, F;NOORDERGRAAF, A
介绍了人体全身动脉树线性被动模型的设计、构建和评估。该电气模型的性能在以下方面与真实模型的性能进行了广泛比较：输入阻抗的幅度和相位、沿主动脉的波传播（压力谐波的幅度和相位）以及不同位置的压力和流量的波形。这些比较表明该模型的行为与真实系统非常相似。讨论了短段动脉建模中的一系列改进；尽管这些改进有助于获得与现实更好的一致性，但没有一个对接近核心测量的模型行为产生重大影响。反射在确定系统行为方面发挥着重要作用，并发生在所有分支点。最大的反射系数出现在外围。这些反射系数主要来自动脉树的结构。图中显示了如何根据这些反射来解释输入阻抗和波传播模式的性质。对于大于 2 cps 的频率，大型船舶中的输入阻抗和波传播很大程度上取决于这些船舶本身的特性，而不是负载。这主要是由于系统的架构造成的。外围电阻的变化仅在非常低的频率下影响系统的输入阻抗；主动脉中的波传播也是如此：高频实际上与外周阻力无关。模拟并讨论了一些临床状态。
The design, construction and evaluation of a linear passive model of the human systemic arterial tree are presented. The performance of this electrical model is compared extensively to its real counterpart in the following areas: magnitude and phase of input impedances, wave travel (amplitude and phase of pressure harmonics) along the aorta, and wave shapes of pressures and flows at different locations. These comparisons demonstrate that the model behaves very much like the real system.A series of refinements in the modeling of a short segment of artery is discussed; although these refinements help to obtain better agreement with reality, none has a major effect on the behavior of the model as measured close to the heart.Reflections play a major role in determining the behavior of the system and occur at all branch points. The largest reflection coefficients are found at the periphery. These reflection coefficients result mainly from the architecture of the arterial tree. It is shown how the nature of the input impedance and wave travel pattern can be explained in terms of these reflections.The input impedance and wave travel in large vessels, for frequencies larger than 2 cps, are largely determined by the characteristics of these vessels themselves and not by the load. This is mainly due to the architecture of the system.Alterations in peripheral resistance affect the input impedance of the system only for very low frequencies; the same holds for wave travel in the aorta: the high frequencies are virtually independent of the peripheral resistance.Some clinical states are simulated and discussed.