Hypervalent Iodine-Mediated Beckmann Rearrangement of Ketoximes
Hypervalent Iodine-Mediated Beckmann Rearrangement of Ketoximes
复制标题
高价碘介导的酮肟贝克曼重排
作者：
Oishi;Ryohei; Segi;Kazutoshi; Hamamoto;Hiromi; Nakamura;Akira; Maegawa;Tomohiro; Miki;Yasuyoshi
我们发展了一种在温和条件下使用高价碘试剂的贝克曼重排反应。酮肟与高价碘反应生成相应的酮，但高价碘和刘易斯酸的预混合对促进贝克曼重排是有效的。芳香族和脂肪族酮肟以良好至高的产率转化为它们相应的酰胺。
We developed a Beckmann rearrangement employing hypervalent iodine reagent under mild conditions. The reaction of ketoxime with hypervalent iodine afforded the corresponding ketone, but premixing of hypervalent iodine and a Lewis acid was effective for promoting Beckmann rearrangement. Aromatic and aliphatic ketoximes were converted into their corresponding amides in good to high yields.