Mussel-Inspired Anchoring of Polymer Loops That Provide Superior Surface Lubrication and Antifouling Properties.
Mussel-Inspired Anchoring of Polymer Loops That Provide Superior Surface Lubrication and Antifouling Properties.
复制标题
DOI：
10.1021/acsnano.5b06066
复制
发表时间：
2016-01-26
期刊：
影响因子：
17.1
通讯作者：
Hawker CJ
中科院分区：
文献类型：
--
作者：
Kang T;Banquy X;Heo J;Lim C;Lynd NA;Lundberg P;Oh DX;Lee HK;Hong YK;Hwang DS;Waite JH;Israelachvili JN;Hawker CJ
我们描述了坚固锚定的三嵌段共聚物，它们在表面上采用环状构象，并赋予它们前所未有的润滑和防污性能。三嵌段有两个带儿茶酚锚定基团的末端嵌段和一个环状聚环氧乙烷（PEO）中间嵌段。这些环调节两个云母表面之间强烈的空间排斥力。当以~2.5 μm/s的恒定速度剪切时，在~2 ~ 3 MPa的压力下，表面表现出极低的摩擦系数，为~0.002 ~ 0.004，没有任何损伤迹象，接近大多数生物轴承系统。此外，与随机线圈或刷状构象中的聚合物相比，聚合物环增强了对细胞粘附和增殖的抑制。这些结果表明，强锚定的聚合物环对于高润滑和低细胞粘附是有效的，并且代表了高性能生物医学涂料开发的一个有希望的候选者。
We describe robustly anchored triblock copolymers that adopt loop conformations on surfaces and endow them with unprecedented lubricating and antifouling properties. The triblocks have two end blocks with catechol-anchoring groups and a looping poly(ethylene oxide) (PEO) midblock. The loops mediate strong steric repulsion between two mica surfaces. When sheared at constant speeds of ~2.5 μm/s, the surfaces exhibit an extremely low friction coefficient of ~0.002–0.004 without any signs of damage up to pressures of ~2–3 MPa that are close to most biological bearing systems. Moreover, the polymer loops enhance inhibition of cell adhesion and proliferation compared to polymers in the random coil or brush conformations. These results demonstrate that strongly anchored polymer loops are effective for high lubrication and low cell adhesion and represent a promising candidate for the development of specialized high-performance biomedical coatings.