Rheological evaluation of gelatin gels prepared with a citric acid derivative as a novel cross-linker
Rheological evaluation of gelatin gels prepared with a citric acid derivative as a novel cross-linker
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DOI：
10.1016/j.msec.2004.08.021
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发表时间：
2004-12
期刊：
影响因子：
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通讯作者：
H. Aoki;T. Taguchi;H. Saito;Hisatoshi Kobayashi;K. Kataoka;J. Tanaka
中科院分区：
文献类型：
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作者：
H. Aoki;T. Taguchi;H. Saito;Hisatoshi Kobayashi;K. Kataoka;J. Tanaka
我们开发了一种由生物分子和具有活性酯基的柠檬酸衍生物（CAD）组成的组织粘合剂。然而，为了将其应用于生物医学，凝胶化时间和凝胶强度必须根据器官和损伤而不同。在这项研究中，我们加入离子盐或有机溶剂的胶粘剂前体溶液，以改变胶粘剂的性能，如硬化期和强度。用流变仪测定了不同条件下凝胶的成胶时间和机械强度。我们发现，加入二价阴离子和二甲基亚砜（DMSO）缩短凝胶时间，增加机械强度。
We developed a tissue adhesive consisting of biomolecules and a citric acid derivative (CAD) with active ester groups. To apply it biomedically, however, gelation time and gel strength must be different depending on the organ and injury. In this study, we added ionic salts or organic solvent to adhesive precursor solutions to modify adhesive properties, such as hardening period and strength. We measured gelation time and mechanical strength of gels under different conditions using a rheometer. We found that adding divalent anions and dimethyl sulfoxide (DMSO) shortened gelation time and increased mechanical strength.