Prevalence, comorbidity, and risk factors for functional bowel symptoms: a population-based survey in Northern Norway
Prevalence, comorbidity, and risk factors for functional bowel symptoms: a population-based survey in Northern Norway
复制标题
DOI：
10.3109/00365521.2012.688215
复制
发表时间：
2012-11-01
影响因子：
1.9
通讯作者：
Paulssen, Eyvind J.
中科院分区：
文献类型：
--
作者：
Breckan, Ragnar K.;Asfeldt, Anne Mette;Paulssen, Eyvind J.
目标。评估挪威北部功能性肠（FB）症状的发生，并描述性别差异、合并症及其与危险因素（包括幽门螺杆菌感染）的关系。材料和方法。来自Bodo和Sorreisa社区的成年受试者（18-85岁）被邀请完成胃肠症状调查问卷，并提供粪便样本用于评估幽门螺杆菌。结果。在3927名被邀请的受试者中，1731人（44.1%）回答了问卷调查，1416人（36.0%）提供了粪便样本。25%的患者出现功能性肠道症状，女性更常见（28.6%）。不同性别的症状模式仅在便秘方面有所不同。FB症状的出现与胃食管反流症状、头痛、头晕、心悸、睡眠障碍和肌肉骨骼症状显著相关。心理测量特征也更为普遍：应对能力低下、情绪低落、时间压力大、健康自我评价低。在多元回归模型中，影响报告FB症状的因素为男性（OR 0.71, 95% CI(0.52; 0.96)）、年龄50-69岁或>= 70岁（OR 0.49（0.30; 0.80）和0.40(0.21;0.79)）、肥胖（OR 1.61(1.05; 2.47)）、使用非甾体抗炎药（OR 2.50(1.63; 3.83)）和既往腹部手术（OR 1.54(1.05; 2.26)）。幽门螺杆菌的存在与FB症状无关。结论。功能性肠道症状是普遍存在的，但我们的研究结果可能倾向于自我选择偏差。FB症状具有显著的合并症负担。女性和低年龄是已知的FB症状的危险因素，而使用非甾体抗炎药作为危险因素值得进一步澄清。
Objective. To assess the occurrence of functional bowel (FB) symptoms in Northern Norway, and to describe gender differences, comorbidity, and association to risk factors, including Helicobacter pylori infection. Materials and methods. Adult subjects (18-85 years) from the communities Bodo and Sorreisa were invited to complete a questionnaire on gastrointestinal symptoms, and to provide stool samples for assessment of H. pylori. Results. Of 3927 invited subjects, 1731(44.1%) responded to the questionnaire and 1416 (36.0%) provided stool samples. Functional bowel symptoms were found in 25%, somewhat more frequent in females (28.6%). Symptom pattern differed between genders only with regard to constipation. Presence of FB symptoms was significantly associated with gastroesophageal reflux symptoms, headache, dizziness, palpitations, sleep disturbances, and musculoskeletal symptoms. Psychometric traits were also more prevalent: feeling of low coping ability, feeling depressed, feeling of time pressure, and a low self-evaluation of health. In a multivariate regression model, factors that influenced the reporting FB symptoms were male gender (OR 0.71, 95% CI (0.52; 0.96)), age 50-69 years or >= 70 years (OR 0.49 (0.30; 0.80) and 0.40 (0.21; 0.79)), obesity (OR 1.61 (1.05; 2.47)), NSAID use (OR 2.50 (1.63; 3.83)), and previous abdominal surgery (OR 1.54 (1.05; 2.26)). The presence of H. pylori was not associated with FB symptoms. Conclusions. Functional bowel symptoms are prevalent, but our findings may be prone to self-selection bias. FB symptoms carry a significant burden of comorbidity. Female gender and low age are known risk factors for FB symptoms, whereas NSAID use as a risk factor deserves further clarification.