Mnemonic functions of dorsal striatum and hippocampus in aversive conditioning
Mnemonic functions of dorsal striatum and hippocampus in aversive conditioning
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DOI：
10.1016/s0166-4328(02)00402-3
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发表时间：
2003-06
影响因子：
2.7
通讯作者：
N. White;J. A. Salinas
中科院分区：
文献类型：
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作者：
N. White;J. A. Salinas
本实验考察了巴甫洛夫厌恶条件反射中海马和背纹状体的记忆功能。大鼠在一次训练中通过呈现三个成对的音调和脚震进行训练。训练结束后，立即在海马背侧或背侧纹状体中注射d-安非他明或载药。24小时后，条件冻结（通过红外运动探测器测量运动停止）对实验环境和音调的影响分别进行测量。与载体注射相比，海马背侧注射安非他明显著增加了对情境的条件冻结，但对音调没有影响。背纹状体注射增加了对背景和音调的条件冻结。这些结果与损伤实验结果相一致，表明海马只参与情境CSs的厌恶条件反射，背纹状体参与情境和离散线索CSs的厌恶条件反射。讨论了这两种结构与杏仁核在条件冻结调解中的作用。
These experiments examined the mnemonic functions of hippocampus and dorsal striatum in Pavlovian aversive conditioning. Rats were trained in a single session by presenting three paired tones and footshocks. Immediately after training, they were given microinjections of d-amphetamine or vehicle into either dorsal hippocampus or dorsal striatum. Twenty-four hours later conditioned freezing (measured as cessation of movement by infrared motion detectors) to the experimental context and to the tone were measured separately. Compared to vehicle injections, amphetamine injections into dorsal hippocampus significantly increased conditioned freezing to the context but not to the tone. Injections into dorsal striatum increased conditioned freezing to both the context and the tone. These results converge with findings from lesion experiments suggesting that hippocampus is involved in aversive conditioning with contextual CSs only, and that dorsal striatum is involved in aversive conditioning with both contextual and discrete cue CSs. The functions of the these two structures in relation to that of the amygdala in the mediation of conditioned freezing are discussed.