PLASMA GABA LEVELS IN NEUROLOGICAL PATIENTS UNDER TREATMENT WITH VALPROIC ACID
PLASMA GABA LEVELS IN NEUROLOGICAL PATIENTS UNDER TREATMENT WITH VALPROIC ACID
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DOI：
10.1016/0024-3205(81)90504-x
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发表时间：
1981-01-01
期刊：
影响因子：
6.1
通讯作者：
SCHMIDT, D
中科院分区：
文献类型：
--
作者：
LOSCHER, W;SCHMIDT, D
研究了慢性丙戊酸钠盐治疗对5例住院患者血浆GABA浓度的影响。在每日剂量1500-3000毫克VPA钠治疗的2-10天内，与对照日相比，GABA水平增加到30 - 80%。5名患者中有3名患者的这种增加是短暂的。在19例服用VPA药物的癫痫患者中，血浆GABA水平比作为对照的非癫痫患者高40%。讨论了VPA引起的血浆GABA升高反映脑GABA含量升高的可能性。
The effect of chronic treatment with valproic acid (VPA), administered as its sodium salt, on the plasma concentrations of GABA was studied in 5 in-patients. Within 2–10 days of treatment with daily doses of 1500–3000 mg sodium VPA GABA levels increased to 30–80 % compared to control days. This increase was transient in 3 out of 5 patients. In 19 epileptic patients under VPA medication plasma GABA levels were 40 % higher than those determined in non-epileptic patients serving as controls. The possibility that the increase in plasma GABA induced by VPA reflects similar increases in brain GABA content is discussed.