Prozone effect of serum IgE levels in a case of plasma cell leukemia.
Prozone effect of serum IgE levels in a case of plasma cell leukemia.
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DOI：
10.1186/1756-8722-3-32
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发表时间：
2010-09-10
影响因子：
28.5
通讯作者：
Dolloff NG
中科院分区：
文献类型：
--
作者：
Talamo G;Castellani W;Dolloff NG
We describe a case of multiple myeloma (MM) and secondary plasma cell leukemia (PCL) secreting IgE-kappa immunoglobulin. To our knowledge, only 2 cases of IgE-producing secondary PCL have been reported in the medical literature. In our patient, the only tumor marker available for monitoring the therapeutic response to chemotherapy and allogeneic stem cell transplantation was the quantitative M component at serum protein electrophoresis (SPEP), because serum free light chains were in the normal range, Bence-Jones proteinuria was absent, and quantitative serum IgE levels provided inaccurate and erratic results, due to the prozone effect. This is a laboratory phenomenon that occurs when antigen excess interferes with antibody-based methods requiring immune complex formation for detection. It is important to recognize the presence of a prozone effect, because it can produce falsely normal results, and therefore it could lead clinicians to incorrect assessment of the response to therapy.
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影响因子：
20.3
作者：
Avet-Loiseau, H;Garand, R;Bataille, R
通讯作者：
Bataille, R
影响因子：
2.1
作者：
Takemura, Yuzuru;Ikeda, Masanobu;Ichinohasama, Ryo
通讯作者：
Ichinohasama, Ryo
影响因子：
3.1
作者：
Hayes, Michael J.;Carey, John L.;Keren, David F.
通讯作者：
Keren, David F.
影响因子：
5.1
作者：
Wang, Man-ling;Huang, Qiang;Yang, Tian-xin
通讯作者：
Yang, Tian-xin
DOI：
10.1080/00365519950185472
发表时间：
1999-10-01
影响因子：
2.1
作者：
Kairemo, KJA;Lindberg, M;Prytz, M
通讯作者：
Prytz, M