THIAZIDE-INDUCED PHOTOSENSITIVITY - A STUDY OF 33 SUBJECTS
THIAZIDE-INDUCED PHOTOSENSITIVITY - A STUDY OF 33 SUBJECTS
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DOI：
10.1111/j.1365-2133.1987.tb04893.x
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发表时间：
1987-06-01
影响因子：
10.3
通讯作者：
FRAINBELL, W
中科院分区：
文献类型：
--
作者：
ADDO, HA;FERGUSON, J;FRAINBELL, W
描述了 33 名噻嗪类光敏性受试者的临床特征、作用范围和随后的病程。该反应本质上似乎具有光毒性。所涉及的波长是较长的 UVA 波段，并且通常也包括较短的 UVB 波段。在大多数情况下，停药后临床反应消失，作用谱恢复正常。在少数持续存在光敏性的受试者中，无论是临床反应还是异常作用谱，或两者兼而有之，要么存在特定的光性皮肤病，要么正在服用另一种潜在的光敏药物。在任何情况下，都没有证据表明停用噻嗪类药物后会诱发长期慢性光敏反应（持续光反应）。
The clinical features, action spectrum and subsequent course, are described in 33 subjects with thiazide-induced photosensitivity. The reaction appeared to be phototoxic in nature. The wavelengths involved were those of the longer UVA and, not infrequently, also the shorter UVB wavebands. In most instances withdrawal of the drug resulted in clearance of the clinical reaction and a return of the action spectrum to normal. In the few subjects in whom the photosensitivity persisted, either in the form of the clinical reaction or an abnormal action spectrum, or both, either a specific photodermatosis was present or another potentially photoactive drug was being taken. In no instance, was there evidence of the induction of long-term chronic photosensitivity (persistent light reaction) following the withdrawal of the thiazide drug.