Effect of the general anesthetic halothane on the activity of the transverse tubule Ca(2+)-activated K+ channel.
Effect of the general anesthetic halothane on the activity of the transverse tubule Ca(2+)-activated K+ channel.
复制标题
全身麻醉氟烷对横管Ca(2)激活K通道活性的影响。
DOI：
10.1016/0014-5793(93)80338-u
复制
发表时间：
1993
期刊：
影响因子：
3.5
通讯作者：
Gable,K
中科院分区：
文献类型：
--
作者：
Beeler,T;Gable,K
研究了全身麻醉剂氟烷对平面脂质双层中大鼠骨骼肌Ca 2+激活K+通道活性的影响。临床范围内的氟烷浓度（1.0-0.2 mM）通过Ca 2+和膜电位改变通道的调节。当Ca 2+浓度在10 ~ 250 μM之间，膜电位在0 ~ −30 mV之间时，氟烷会显著降低开放状态的概率，而不会改变通道电导。结果表明，氟烷可直接作用于Ca 2+激活的K+通道或其脂质环境，以改变通道门控动力学。
The effect of the general anesthetic halothane on the activity of the rat skeletal muscle Ca2+‐activated K+channel in planar lipid bilayers was investigated. Halothane concentrations in the clinical range (1.0–0.2 mM) alter the regulation of the channel by both Ca2+and membrane potential. At Ca2+concentrations between 10 and 250 μM and membrane potentials between 0 and −30 mV, halothane significantly decreases the open state probability without changing the channel conductance. The results demonstrate that halothane can act directly on the Ca2+‐activated K+channel or its lipid environment to alter the channel gating kinetics.