5HTTLPR: White Knight or Dark Blight?
5HTTLPR: White Knight or Dark Blight?
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5HTTLPR：白骑士还是黑暗疫病？
DOI：
10.1021/cn3002224
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发表时间：
2013
影响因子：
5
通讯作者：
Vogt,NicholasM
中科院分区：
文献类型：
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作者：
Murphy,DennisL;Maile,MichelleS;Vogt,NicholasM
在2012年上半年发表的100多篇关于SLC 6A 4的神经科学遗传学报告中，>40%的报告数据仅来自5-羟色胺转运蛋白连接启动子区[5 HTTLPR] indel的基因分型，忽略了两个邻近SNP的基因分型，这两个SNP基本上改变了5 HTTLPR等位基因频率和功能。这些论文中有25%没有报告受试者的种族基因型，这是另一个改变等位基因频率的因素。因此，这个领域看起来很愚蠢。通过关注更完整的基因分型和受试者样本报告方法，将更好地服务于当前和未来的科学进步。
In over 100 neuroscience genetics reports onSLC6A4published in the first part of 2012, >40% reported data from genotyping only the serotonin transporter-linked promoter region [5HTTLPR] indel, omitting genotyping of two nearby SNPs that substantially alter 5HTTLPR allele frequencies and functionality. And 25% of these papers did not report ethnicity of the subjects genotyped, another factor that alters allele frequencies. This field thus seems stultified. Improved science for the present and future will be better served by attention to more complete methods for genotyping and subject sample reporting.