Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy.
Reactivation of a Vaccine Escape Hepatitis B Virus Mutant in a Cambodian Patient During Anti-Hepatitis C Virus Therapy.
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DOI：
10.3389/fmed.2018.00097
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发表时间：
2018
影响因子：
3.9
通讯作者：
Lauer G
中科院分区：
文献类型：
--
作者：
Fusco DN;Ganova-Raeva L;Khudyakov Y;Punkova L;Mohamed A;Cheon SSY;Koirala P;Andersson KL;Jourdain G;Sureau C;Chung RT;Lauer G
一名76岁的柬埔寨男子同时感染了B型肝炎病毒（HBV）和丙型肝炎病毒（HCV）6c-1。尽管抗-HBs水平高于保护阈值，但HBV DNA可间歇性检测。在治疗HCV期间，HBV DNA水平升高。测序显示多个突变，包括疫苗逃逸突变和预测增强适应性的突变。该病例代表在直接作用抗病毒治疗期间HBV疫苗逃逸突变体的恶化。
A 76-year-old Cambodian man co-infected with hepatitis B virus (HBV) and hepatitis C virus (HCV) 6c-1 presented for care. HBV DNA was intermittently detectable despite anti-HBs levels being above the protective threshold. During treatment for HCV, HBV DNA levels increased. Sequencing revealed multiple mutations including vaccine escape mutation and mutations predicted to enhance fitness. This case represents exacerbation of an HBV vaccine escape mutant during a direct-acting antiviral therapy.