What is needed for next-generation ecological and evolutionary genomics?
What is needed for next-generation ecological and evolutionary genomics?
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DOI：
10.1016/j.tree.2012.07.014
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发表时间：
2012-12-01
影响因子：
16.8
通讯作者：
Landry, Christian R.
中科院分区：
文献类型：
--
作者：
Pavey, Scott A.;Bernatchez, Louis;Landry, Christian R.
生态进化基因组学(EEG)旨在将基因功能和基因组特征与表型和生态因素联系起来。尽管技术的快速发展使得核心问题能够在前所未有的分子细节水平上得到解决，但它们并没有缓解EEG的主要挑战之一，即很大一部分基因仍然没有任何注释。在这里，我们提出了两个解决方案来应对这一挑战。第一种解决方案是以数据库的形式重新组合基因、生物属性以及非生物和生物条件之间的联系。这个数据库将通过允许跨研究和分类群的交叉参考来产生对基因的生态注释。我们的第二个解决方案是使用新的功能技术来表征与应对生态挑战有关的基因。
Ecological and evolutionary genomics (EEG) aims to link gene functions and genomic features to phenotypes and ecological factors. Although the rapid development of technologies allows central questions to be addressed at an unprecedented level of molecular detail, they do not alleviate one of the major challenges of EEG, which is that a large fraction of genes remains without any annotation. Here, we propose two solutions to this challenge. The first solution is in the form of a database that regroups associations between genes, organismal attributes and abiotic and biotic conditions. This database would result in an ecological annotation of genes by allowing cross-referencing across studies and taxa. Our second solution is to use new functional techniques to characterize genes implicated in the response to ecological challenges.