In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror
In vivo three-dimensional spectral domain endoscopic optical coherence tomography using a microelectromechanical system mirror
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DOI：
10.1364/ol.32.003239
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发表时间：
2007-11-15
期刊：
影响因子：
3.6
通讯作者：
Chen, Zhongping
中科院分区：
文献类型：
--
作者：
Jung, Woonggyu;McCormick, Daniel T.;Chen, Zhongping
活检是一种众所周知的医学测试，用于评估组织异常。活检标本是从病变部分侵入性采集的，经过化学处理后通过显微镜观察。然而，通过活检进行的诊断不仅会因样本的深度和位置而变化，而且还可能损坏样本。此外，只能获得有限数量的标本，因此无法观察整个组织形态。我们通过采用双轴微机电系统扫描镜的光学相干断层扫描介绍了三维（3-D）内窥镜光学活检。由于该技术提供了高分辨率、无创、直接和多重组织可视化，因此它可以作为具有先进性能的临床活检。该设备与传统内窥镜集成，用于生成人类和动物体内 3D 临床图像。 (c) 2007 年美国光学学会。
A biopsy is a well-known medical test used to evaluate tissue abnormality. Biopsy specimens are invasively taken from part of a lesion and visualized by microscope after chemical treatment. However, diagnosis by means of biopsy is not only variable due to depth and location of specimen but may also damage the specimen. In addition, only a limited number of specimens can be obtained, thus, the entire tissue morphology cannot be observed. We introduce a three-dimensional (3-D) endoscopic optical biopsy via optical coherence tomography employing a dual-axis microelectromechanical system scanning mirror. Since this technique provides high-resolution, noninvasive, direct, and multiple visualization of tissue, it could function as a clinical biopsy with advanced performance. The device was integrated with a conventional endoscope and utilized to generate in vivo 3-D clinical images in humans and animals. (c) 2007 Optical Society of America.