Motion-specific laryngeal reinnervation using muscle-nerve-muscle neurotization
Motion-specific laryngeal reinnervation using muscle-nerve-muscle neurotization
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DOI：
10.1177/000348940111000901
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发表时间：
2001-09-01
影响因子：
1.4
通讯作者：
Kuzon, WM
中科院分区：
文献类型：
--
作者：
Hogikyan, ND;Johns, MM;Kuzon, WM
目前还没有一种治疗方法可以可靠地恢复瘫痪声带的生理运动。本研究的目的是测试以下假设：1）可以在猫喉部肌肉中诱导肌肉-神经-肌肉（M-N-M）神经化，2）M-N-M 神经化可以恢复瘫痪声带的运动。肌肉-神经-肌肉神经化可以被定义为通过轴突对去神经肌肉进行重新神经支配，轴突被诱导从受神经支配的肌肉内的神经发芽，然后穿过插入其和目标去神经肌肉之间的神经移植物。瘫痪的喉部肌肉可以通过对侧配对肌肉的轴突重新神经支配，从而实现运动特异性的神经支配。将 18 只成年猫分为假手术组、半喉去神经组和 M-N-M 重新神经支配甲杓肌组。 6 只重新神经支配的动物中有 5 只在神经移植物中具有轴突的组织学证据，6 只动物中的 4 只诱发了交叉神经支配的肌电图证据，而 1 只具有交叉神经支配的肌电图证据。 6 恢复了适当的分阶段内收。该技术具有巨大的潜力，值得进一步研究。
There is no current treatment method that can reliably restore physiologic movement to a paralyzed vocal fold. The purposes of this study were to test the hypotheses that 1) muscle-nerve-muscle (M-N-M) neurotization can be induced in feline laryngeal muscles and 2) M-N-M neurotization can restore movement to a paralyzed vocal fold. Muscle-nerve-muscle neurotization can be defined as the reinnervation of a denervated muscle via axons that are induced to sprout from nerves within an innervated muscle and that then traverse a nerve graft interposed between it and the target denervated muscle. A paralyzed laryngeal muscle could be reinnervated by axons from its contralateral paired muscle, thus achieving motion-specific reinnervation. Eighteen adult cats were divided into sham, hemilaryngeal-denervated, and M-N-M-reinnervated thyroarytenoid muscle groups. Five of the 6 reinnervated animals had histologic evidence of axons in the nerve graft, 4 of the 6 had evoked electromyographic evidence of crossed reinnervation, and I of the. 6 had a return of appropriately phased adduction. This technique has great potential and should be further investigated.