Swept source/Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit.
Swept source/Fourier domain polarization sensitive optical coherence tomography with a passive polarization delay unit.
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DOI：
10.1364/oe.20.010229
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发表时间：
2012-04-23
期刊：
影响因子：
3.8
通讯作者：
Fujimoto JG
中科院分区：
文献类型：
--
作者：
Baumann B;Choi W;Potsaid B;Huang D;Duker JS;Fujimoto JG
偏振敏感光学相干断层扫描（PS-OCT）是一种功能成像方法，它利用样品的光偏振特性提供额外的对比度。本文描述了基于1050 nm、100 kHz轴向扫描速率的高速扫频光源/傅立叶域OCT的PS-OCT，采用单模光纤和多路复用方法。与先前报道的PS-OCT复用方案不同，该方法使用无源偏振延迟单元，并且不需要有源偏振调制装置。这一进步降低了系统成本，避免了复杂的同步要求。在样品光路中实现偏振延迟单元，以便同时以两种不同的偏振状态照射样品。采用双平衡检测方法检测两个输入状态的深度复用信号的正交偏振分量。使用Jones演算计算PS-OCT图像。在人和大鼠视网膜中进行3D PS-OCT成像。除标准OCT图像外，还使用对比度形式的双折射和去偏振生成PS-OCT图像。使用PS-OCT图像中包含的额外对比度和信息证明了增强的组织区分度以及样本属性的定量测量。
Polarization sensitive optical coherence tomography (PS-OCT) is a functional imaging method that provides additional contrast using the light polarizing properties of a sample. This manuscript describes PS-OCT based on ultrahigh speed swept source / Fourier domain OCT operating at 1050nm at 100kHz axial scan rates using single mode fiber optics and a multiplexing approach. Unlike previously reported PS-OCT multiplexing schemes, the method uses a passive polarization delay unit and does not require active polarization modulating devices. This advance decreases system cost and avoids complex synchronization requirements. The polarization delay unit was implemented in the sample beam path in order to simultaneously illuminate the sample with two different polarization states. The orthogonal polarization components for the depth-multiplexed signals from the two input states were detected using dual balanced detection. PS-OCT images were computed using Jones calculus. 3D PS-OCT imaging was performed in the human and rat retina. In addition to standard OCT images, PS-OCT images were generated using contrast form birefringence and depolarization. Enhanced tissue discrimination as well as quantitative measurements of sample properties was demonstrated using the additional contrast and information contained in the PS-OCT images.