Postintervention effect of nicotine replacement therapy on smoking reduction in smokers who are unwilling to quit: Randomized trial
Postintervention effect of nicotine replacement therapy on smoking reduction in smokers who are unwilling to quit: Randomized trial
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DOI：
10.1097/01.jcp.0000115666.45074.d6
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发表时间：
2004-04-01
影响因子：
2.9
通讯作者：
Perneger, TV
中科院分区：
文献类型：
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作者：
Etter, JF;Laszlo, E;Perneger, TV
本研究的目的是评估尼古丁替代疗法在6个月治疗结束后1.5年内对减少卷烟消费量的干预后效果。从普通人群中招募无意戒烟的重度吸烟者，并随机分配至尼古丁治疗组（选择15 mg尼古丁贴片、4 mg尼古丁口香糖和/或10 mg尼古丁吸入器，n = 265）、匹配安慰剂产品组（n = 269）或无干预组（n = 389）。产品通过邮件发送给与会者。教育仅限于一本小册子。在923名参与者中，879名（95%）在随机化后6个月接受随访，846名（92%）在26个月后接受随访。所有组的平均基线消费量为30支/天。6个月后，尼古丁组的香烟消耗量平均减少了10.9支/天，安慰剂组减少了8.7支/天，对照组减少了4.9支/天（所有成对比较的P均小于或等于0.02）。26个月后，与基线相比，尼古丁组的卷烟消费量平均减少了9.8支/天，安慰剂组为7.7支/天，对照组为7.7支/天（尼古丁与安慰剂或对照组：P小于或等于0.03）。两年后，各组的戒烟率没有显著差异（尼古丁11.7%，安慰剂9.3%，对照组10.0%; P = 0.6）。因此，尼古丁替代疗法对减少吸烟量的轻微影响在6个月治疗结束后维持了1.5年，但最初观察到的安慰剂效应没有维持。减少吸烟的尼古丁替代疗法对戒烟没有有害影响。
The objective of this study was to assess the post-intervention effect of nicotine replacement therapy on reduction of cigarette consumption 1.5 years after the end of a 6-month treatment. Heavy smokers who had no intention of quitting smoking were recruited from the general population and were randomly assigned to a treatment of nicotine (choice of a 15-mg nicotine patch, a 4-mg nicotine gum, and/or a 10-mg nicotine inhaler, n = 265), matching placebo products (n = 269), or no intervention (n 389). Products were sent to participants by mail. Education was limited to a booklet. Of 923 participants, 879 (95%) were followed 6 months after randomization and 846 (92%) were followed after 26 months. Mean baseline consumption was 30 cigarettes/day in all groups. After 6 months, cigarette consumption had decreased by a mean of 10.9 cigarettes/day in the nicotine group, 8.7 in the placebo group, and 4.9 among controls (P less than or equal to 0.02 for all pairwise comparisons). After 26 months, compared with baseline, cigarette consumption had decreased by a mean of 9.8 cigarettes/day in the nicotine group, 7.7 in the placebo group, and 7.7 among controls (nicotine vs. placebo or control: P less than or equal to 0.03). After 2 years, smoking cessation rates did not differ significantly among groups (nicotine 11.7%, placebo 9.3%, control, 10.0%; P = 0.6). Thus, a slight effect of nicotine replacement therapy on reduction of cigarette consumption was maintained 1.5 years after the end of the 6-month treatment, but the initially observed placebo effect was not maintained. Nicotine replacement therapy for smoking reduction had no deleterious impact on smoking cessation.