Elimination of spatial interference in PRESS-localized editing spectroscopy
Elimination of spatial interference in PRESS-localized editing spectroscopy
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DOI：
10.1002/mrm.21407
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Matson, Gerald B.
中科院分区：
文献类型：
--
作者：
Kaiser, Lana G.;Young, Karl;Matson, Gerald B.
人脑中γ-氨基丁酸（GABA）的非环境生物学检测受到低浓度和与其他代谢物光谱重叠的阻碍。流行的MEGA-PRESS（PRESS：点分辨光谱序列）方法允许从其他代谢物中分离GABA的光谱，但由于4室伪影而遭受显著的信噪比（SNR）降低。研究了另一种PRESS定位技术（PRESS+4），并使用数值模拟、体模和体内实验与MEGA-PRESS进行了比较。结果表明，虽然MEGA-PRESS方法遭受显着的信号损失（差谱约20%），在PRESS+4中的GABA信号强度相比，在4 T的非本地化的条件下，仅减少了2%。改进后的方法保留了流行的MEGA-PRESS的重要特征，如在人脑实验中证明的额外的水抑制和大分子消除。该方法不仅限于GABA J-差异编辑，而且可以应用于任何基于GABA的实验。它应该被证明在更高的领域特别有用，其中4室伪影特别有害。
Unambiguous detection of gamma-amino butyric acid (GABA) in the human brain is hindered by low concentration and spectral overlap with other metabolites. The popular MEGA-PRESS (PRESS: point-resolved spectroscopic sequence) method allows spectral separation of GABA from other metabolites, but suffers from a significant signal-to-noise ratio (SNR) reduction due to the 4-compartment artifact. An alternative PRESS localization technique (PRESS+4) was investigated and compared to MEGA-PRESS using numerical simulations, phantom, and in vivo experiments. It was shown that while the MEGA-PRESS method suffers significant signal loss (approximate to 20% for the difference spectrum), GABA signal intensity in PRESS+4 is reduced by only 2% compared to the nonlocalized condition at 4T. The improved method retains important features of the popular MEGA-PRESS such as additional water suppression and macromolecular elimination as demonstrated in human brain experiments. This method is not limited to GABA J-difference editing, but can be applied in any PRESS-based experiments. It should prove particularly useful at higher field, where the 4-compartment artifact is especially detrimental.