Attenuation of the in vivo toxicity of biomaterials by polydopamine surface modification
Attenuation of the in vivo toxicity of biomaterials by polydopamine surface modification
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DOI：
10.2217/nnm.11.76
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发表时间：
2011-07-01
期刊：
影响因子：
5.5
通讯作者：
Lee, Haeshin
中科院分区：
文献类型：
--
作者：
Hong, Seonki;Kim, Keum Yeon;Lee, Haeshin
聚多巴胺涂层作为一种有用的表面功能化方法正在兴起，因为这种化合物能够在几乎任何材料表面形成纳米级的有机薄膜，这些材料表面可以附着蛋白质、肽、寡核苷酸、金属离子或合成聚合物。聚多巴胺的独特性质使该技术适用于纳米医学。为了方便多多巴胺的使用，毒性评价是非常重要的。本文研究了聚多巴胺的体内毒性。结果：我们发现聚多巴胺作为一种生物相容性层，可以减轻被涂材料固有特性引起的不良生物反应。一步聚多巴胺包被大大降低了对聚乳酸表面的炎症反应，也降低了血液对量子点的免疫反应。结论：我们的研究结果表明，聚多巴胺提供了一个多功能平台，可以降低生物材料接触组织或血液的体内毒性。
Polydopamine coating is emerging as a useful method of surface functionalization due to the ability of this compound to form a nanometer-scale organic thin film on virtually any material surface to which proteins, peptides, oligonucleotides, metal ions or synthetic polymers are able to be attached. The unique properties of polydopamine make this technique suitable for nanomedicine. To facilitate the use of polydopamine, evaluation of toxicity is of great importance. In this article, we investigated the in vivo toxicity of polydopamine. Results: We found that the polydopamine functions as a biocompatible layer, attenuating adverse biological responses caused by intrinsic properties of the coated material. One-step polydopamine coating greatly reduced the inflammatory response to poly-l-lactic acid surfaces and the immunological responses of blood on quantum dots were also reduced. Conclusion: Our results indicate that polydopamine provides a versatile platform that can reduce the in vivo toxicity of biomaterials that contact tissue or blood.