Serotonin modulates induced synaptic activity in the optic tectum of the frog
Serotonin modulates induced synaptic activity in the optic tectum of the frog
复制标题
血清素调节青蛙视顶盖诱导的突触活动
DOI：
10.1016/s0006-8993(97)01230-4
复制
发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
E. Debski
中科院分区：
文献类型：
--
作者：
A. Malayev;E. Debski
视网膜信号在中心位置被调制的程度是未知的。我们试图确定血清素（一种存在于青蛙顶盖视网膜受体层的神经递质）对视网膜顶盖传递的影响。采用急性电刺激视神经顶盖层，模拟视觉输入对视神经顶盖神经元的激活。这种刺激在贴片夹紧的顶盖神经元中引起单突触或多突触电流反应。外用5-羟色胺阻断了这两种诱导电流，5-碳色胺（5-CT），一种5- ht1受体的非选择性激动剂。α -甲基5-羟色胺，一种5- ht2受体的非选择性激动剂，也能阻断多突触反应，但在阻断单突触反应方面不如5-羟色胺或5-CT有效。在顶盖主细胞层的急性电刺激模型中，顶盖细胞间的横向突触相互作用也被血清素、5-CT或α-甲基血清素阻断。目前的数据表明，内源性血清素可能通过调节视网膜和顶盖之间以及顶盖神经元之间的突触传递来强烈影响视觉信号的处理。这种调节很可能是由于，至少部分是由于在直肠细胞亚群中由血清素诱导的向外电流。
The extent to which retinal signals are modulated at central sites is unknown. We sought to determine the effects of serotonin, a neurotransmitter present in the retinorecipient layers of the frog tectum, on retinotectal transmission. Acute electrical stimulation delivered to the retinorecipient layer of optic tectum brain slices was used to model the activation of tectal neurons by visual inputs. This stimulation evoked either a monosynaptic or a polysynaptic current response in patch-clamped tectal neurons. External application of serotonin blocked both of these induced currents as did 5-carbotryptamine (5-CT), a nonselective agonist of 5-HT1receptors. Alpha-methylserotonin, a nonselective agonist of 5-HT2receptors, also blocked polysynaptic responses but was less effective than either serotonin or 5-CT in blocking monosynaptic ones. Lateral synaptic interactions between tectal cells, modeled by acute electrical stimulation in the main cellular layer of the tectum, were also blocked by serotonin, 5-CT or α-methylserotonin. The presented data suggest that endogenous serotonin may strongly affect visual signal processing by modulating synaptic transmission between both the retina and the tectum as well as between tectal neurons. This modulation is likely to be due, at least in part, to a demonstrated outward current induced by serotonin in a subpopulation of tectal cells.
登录
查看更多内容
青蛙视顶盖非视网膜传入投射的发展和顶盖连接的 P 物质免疫反应性。
DOI：
10.1016/0165-3806(93)90156-5
发表时间：
1993
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Debski,EA;Constantine-Paton,M
通讯作者：
Constantine-Paton,M
影响因子：
2.5
作者：
SPRUSTON, N;JAFFE, DB;JOHNSTON, D
通讯作者：
JOHNSTON, D
影响因子：
7.3
作者：
ISMAIEL, AM;TITELER, M;GLENNON, RA
通讯作者：
GLENNON, RA
豹蛙峡核单侧消融的行为和生理后果。
DOI：
10.1159/000114350
发表时间：
1991
期刊：
Brain, behavior and evolution
影响因子：
--
作者：
Gruberg,ER;Wallace,MT;Caine,HS;Mote,MI
通讯作者：
Mote,MI