Wet or dry: translatable "water mazes" for mice and humans.
Wet or dry: translatable "water mazes" for mice and humans.
复制标题
湿或干：可翻译为小鼠和人类的“水迷宫”。
DOI：
10.1172/jci86071
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Geyer,MarkA
中科院分区：
文献类型：
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作者：
Higa,KerinK;Young,JaredW;Geyer,MarkA
虽然阿尔茨海默病（Alzheimer 's disease， AD）的认知和生物学特征已经广为人知，而且已有AD的小鼠模型，但目前针对AD相关认知缺陷的治疗效果相当有限。开发具有跨物种效度的任务可以更好地预测潜在新疗法的疗效。在本期《jci》中，posin等人展示了Morris水迷宫（一种啮齿类动物空间学习和记忆的常见测试）的虚拟版本，该版本专为人类设计。作者在各自版本的迷宫中测试了AD小鼠模型（表达人类淀粉样蛋白前体蛋白[hAPP]的转基因小鼠）和早期轻度认知障碍（MCI） AD患者。利用新颖的统计方法，他们发现了不同物种之间类似的缺陷，为hAPP模型和虚拟水迷宫的使用提供了支持。重要的是，这项工作为开发潜在的阿尔茨海默病治疗方法提供了合适的样本量建议。
Although the cognitive and biological characteristics of Alzheimer’s disease (AD) are well known and mouse models of AD are available, current treatments for AD-related cognitive deficits have quite limited efficacy. The development of tasks with cross-species validity may enable better prediction of the efficacy of potential new treatments. In this issue of theJCI, Possin et al. present a virtual version of the Morris water maze (a common test of spatial learning and memory for rodents) that is designed for use with humans. The authors tested a mouse model of AD (transgenic mice expressing human amyloid precursor protein [hAPP]) and patients in the earlier mild cognitive impairment (MCI) stage of AD in their respective versions of the maze. Using novel statistical methods, they detected similar deficits across species, providing support for the hAPP model and use of the virtual water maze. Importantly, this work enabled recommendations for appropriate sample sizes when developing potential therapeutics for AD.