LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response.
LGP2 is essential for zebrafish survival through dual regulation of IFN antiviral response.
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DOI：
10.1016/j.isci.2022.104821
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发表时间：
2022-08-19
期刊：
影响因子：
5.8
通讯作者：
Zhang, Yi-Bing
中科院分区：
文献类型：
--
作者：
Gong, Xiu-Ying;Zhang, Qi-Min;Zhao, Xiang;Li, Yi-Lin;Qu, Zi-Ling;Li, Zhi;Dan, Cheng;Gui, Jian-Fang;Zhang, Yi-Bing
In mammals, LGP2 is the enigmatic RLR family member, being initially believed as an inhibitor of RLR-triggered IFN response but subsequently as an activator of MDA5 signaling and an inhibitor of RIG-I signaling. The contradiction happens to fish LGP2. Here, we generate a lgp2 loss-of-function (lgp2lof/lof) zebrafish mutant, which is highly susceptible to SVCV infection, displaying an initially decreased activation of IFN response and a following increased one. Mechanistically, zebrafish LGP2 functions as the essential activator of IFN response dependent on MDA5 at the early stage of viral infection but as a negative regulator by impairing mRNA levels of tbk1 and ikki at the late stage of viral infection. The function switch of LGP2 is related to cellular IFN production during viral infection. Our data demonstrate that zebrafish LGP2 is a key homeostatic regulator of IFN response and thus essential for zebrafish survival against SVCV infection. Zebrafish LGP2 is crucial for host survival through initiating IFN response Zebrafish LGP2 exerts dual regulation of IFN response during SVCV infection The function switch of zebrafish LGP2 is related to cellular IFN production Biochemistry; Immunology; Virology;
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影响因子：
3.7
作者：
Childs KS;Randall RE;Goodbourn S
通讯作者：
Goodbourn S
影响因子：
14.9
作者：
Duic I;Tadakuma H;Harada Y;Yamaue R;Deguchi K;Suzuki Y;Yoshimura SH;Kato H;Takeyasu K;Fujita T
通讯作者：
Fujita T
影响因子：
3.8
作者：
Bruns AM;Horvath CM
通讯作者：
Horvath CM
PUM1 是通过抑制 LGP2 来调节先天免疫基因的双相负调节因子
DOI：
10.1073/pnas.1708713114
发表时间：
2017-08-15
影响因子：
11.1
作者：
Liu, Yonghong;Qu, Linlin;Zhou, Grace Guoying
通讯作者：
Zhou, Grace Guoying
影响因子：
5.4
作者：
Komuro, Akihiko;Horvath, Curt M.
通讯作者：
Horvath, Curt M.