Mucus observations in the fertile window: a better predictor of conception than timing of intercourse
Mucus observations in the fertile window: a better predictor of conception than timing of intercourse
复制标题
DOI：
10.1093/humrep/deh173
复制
发表时间：
2004-04-01
影响因子：
6.1
通讯作者：
Colombo, B
中科院分区：
文献类型：
--
作者：
Bigelow, JL;Dunson, DB;Colombo, B
背景：性交基本上只有在排卵日结束的6天受孕间隔内发生才能导致怀孕。在这段时间内的性交时间与受孕概率之间的强烈联系通常归因于有限的精子和卵子寿命。方法：从欧洲自然计划生育中心招募的782名妇女提供了7288个月经周期的前瞻性数据。收集每日性交记录、基础体温和宫颈粘液阴道分泌物。根据相对于排卵的性交时间和1-4分粘液质量来估计受孕的可能性。结果：随着黏液评分的增加，妊娠的日特异性概率有明显的增加趋势。根据黏液评分进行调整后，可育间隔内的日特异性概率变化有限。结论：粘液质量的变化在整个生育期预测在特定的受孕概率观察模式。为了最大限度地提高受孕的可能性，性交应该发生在粘液质量最佳的日子，正如阴道分泌物所观察到的那样，而不管与排卵有关的确切时间。
BACKGROUND: Intercourse results in a pregnancy essentially only if it occurs during the 6-day fertile interval ending on the day of ovulation. The strong association between timing of intercourse within this interval and the probability of conception typically is attributed to limited sperm and egg life times. METHODS: A total of 782 women recruited from natural family planning centres in Europe contributed prospective data on 7288 menstrual cycles. Daily records of intercourse, basal body temperature and vaginal discharge of cervical mucus were collected. Probabilities of conception were estimated according to the timing of intercourse relative to ovulation and a 1-4 score of mucus quality. RESULTS: There was a strong increasing trend in the day-specific probabilities of pregnancy with increases in the mucus score. Adjusting for the mucus score, the day-specific probabilities had limited variability across the fertile interval. CONCLUSIONS: Changes in mucus quality across the fertile interval predict the observed pattern in the day-specific probabilities of conception. To maximize the likelihood of conception, intercourse should occur on days with optimal mucus quality, as observed in vaginal discharge, regardless of the exact timing relative to ovulation.