Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism
Cordyceps Improves Obesity and its Related Inflammation via Modulation of Enterococcus cecorum Abundance and Bile Acid Metabolism
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DOI：
10.1142/s0192415x22500343
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发表时间：
2022-01-01
影响因子：
5.7
通讯作者：
Liu, Qun
中科院分区：
文献类型：
--
作者：
Wu, Guo-Dong;Pan, An;Liu, Qun
肠道菌群失调已被确定为固有炎症的主要介质，其是肥胖症发病机制的基础。冬虫夏草（Cordyceps sinensis（BerK.）SACC.寄生于蛾类蝠蛾科（H. pialusoberthur）具有有效的代谢调节功能。然而，潜在的抗肥胖机制在很大程度上仍然未知。在这里，我们证明了冬虫夏草的水提取物可以减轻高脂饮食（HFD）喂养小鼠的葡萄糖和脂质代谢紊乱及其相关炎症。16S rRNA基因测序和微生物组学分析表明，冬虫夏草减少了肠球菌的数量，肠球菌是一种产生胆汁盐水解酶的微生物，可调节肠道中胆汁酸的代谢。重要的是，E。盲肠移植或肝特异性敲除胆汁酸受体法尼醇X受体（FXR），减弱了虫草对HFD诱导的肥胖的保护作用。总之，我们的研究结果揭示了冬虫夏草降糖降脂作用的机制，并表明靶向肠道E。盲肠或肝脏FXR是潜在的抗肥胖和抗炎治疗途径。
Dysbiotic gut microbiota has been identified as a primary mediator of inherent inflammation that underlies the pathogenesis of obesity. Cordyceps comprises the larval body and the stroma of Cordyceps sinensis (BerK.) Sacc. parasiting on Hepialidae larvae of moths (H. pialusoberthur) with potent metabolic regulation functions. The underlying anti-obesity mechanisms, however, remain largely unknown. Here, we demonstrate that the water extract of Cordyceps attenuates glucose and lipid metabolism disorders and its associated inflammation in high-fat diet (HFD)-fed mice. 16S rRNA gene sequencing and microbiomic analysis showed that Cordyceps reduced the amounts of Enterococcus cecorum, a bile-salt hydrolase-producing microbe to regulate the metabolism of bile acids in the gut. Importantly, E. cecorum transplantation or liver-specific knockdown of farnesoid X receptor (FXR), a bile acid receptor, diminished the protective effect of Cordyceps against HFD-induced obesity. Together, our results shed light on the mechanisms that underlie the glucoseand lipid-lowering effects of Cordyceps and suggest that targeting intestinal E. cecorum or hepatic FXR are potential anti-obesity and anti-inflammation therapeutic avenues.