Kainic acid lesions of striatum and decortication reduce specific [3H]sulpiride binding in rats, so D‐2 receptors exist post‐synaptically on corticostriate afferents and striatal neurons
Kainic acid lesions of striatum and decortication reduce specific [3H]sulpiride binding in rats, so D‐2 receptors exist post‐synaptically on corticostriate afferents and striatal neurons
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纹状体和去皮的红藻氨酸损伤减少了大鼠中特异性[3H]舒必利的结合，因此 D-2 受体存在于突触后的皮质纹状传入神经元和纹状体神经元上
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
C. Marsden
中科院分区：
文献类型：
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作者：
A. Theodorou;C. Reavill;P. Jenner;C. Marsden
与完整侧相比，大鼠纹状体单侧红藻氨酸损伤使纹状体[3 H]螺哌隆和[3 H]舒必利特异性结合位点（Bmax）分别降低52%和67%。[3 H]螺哌隆结合的解离常数（KD）不变，但[3 H]]舒必利结合的解离常数降低。在单侧去皮质动物中，特异性纹状体[3 H]螺哌隆和[3 H]舒必利结合分别减少了22%和37%，但KD没有变化。内侧前脑束的单侧6-羟基多巴胺损伤未引起纹状体[3 H]螺哌隆结合位点或KD值的变化，但使[3 H]舒必利结合位点增加27%，KD无变化。这些数据支持D-2受体位于皮质-纹状体谷氨酸纤维上的假设，但也表明纹状体神经元的细胞体上存在D-1和D-2受体。
Unilateral kainic acid lesions of rat striatum reduced specific striatal [3H]spiperone and [3H]sulpiride binding sites (Bmax) by 52 and 67% respectively compared with the intact side. The dissociation constant (KD) for [3H]spiperone binding was unchanged but that for [3H]]sulpiride binding was reduced. Specific striatal [3H]spiperone and [3H]sulpiride binding was reduced by 22 and 37% respectively in unilateral decorticate animals, but there was no change in KD. Unilateral 6‐hydroxydopamine lesions of the medial forebrain bundle caused no change in striatal [3H]spiperone binding sites or KD value, but produced a 27% increase in [3H]sulpiride binding sites with no change in KD. These data support the hypothesis of D‐2 receptors located on cortico‐striate glutamate fibres, but also indicate the presence of both D‐1 and D‐2 receptors on the cell bodies of striatal neurons.