Methylation of the WNT5A Gene is Frequently Detected in Early Gastric Carcinoma
Methylation of the WNT5A Gene is Frequently Detected in Early Gastric Carcinoma
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DOI：
10.5754/hge09664
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发表时间：
2012-11-01
影响因子：
--
通讯作者：
Sanada, Yutaka
中科院分区：
文献类型：
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作者：
Hibi, Kenji;Sakata, Makiko;Sanada, Yutaka
背景/目的：最近有报道称，WNT5A 甲基化在结直肠癌中频繁检测到。然而，WNT5A甲基化与胃癌特征之间的关系仍不清楚。方法：采用定量甲基化特异性PCR（qMSP）检测38例胃癌患者的原发癌和相应正常组织中WNT5A基因的甲基化状态，并评估甲基化状态与临床病理结果之间的相关性。结果：在 38 例原发性胃癌中，有 7 例 (18%) 检测到 WNT5A 基因的异常甲基化，表明在胃癌和结直肠癌中也观察到了 WNT5A 甲基化。临床病理数据与甲基化结果相关。肿瘤范围观察到显着差异（p=0.0226）。此外，甲基化肿瘤有早期 TNM 分期的趋势 (p=0.209)。结论：WNT5A 在早期胃癌中更频繁地甲基化。
Background/Aims: Recently, it has been reported that WNT5A methylation was frequently detected in colorectal cancers. However, the relationship between the WNT5A methylation and the characteristics of gastric cancer remains unknown. Methodology: Methylation status of the WNT5A gene was examined in primary carcinomas and the corresponding normal tissues derived from 38 patients with gastric cancer using quantitative methylation-specific PCR (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated. Results: Aberrant methylation of the WNT5A gene was detected in 7 out of the 38 (18%) primary gastric carcinomas, suggesting that the methylation of WNT5A is observed in gastric carcinomas as well as colorectal ones. The clinicopathological data were correlated with the methylation results. A significant difference was observed in the extent of tumor (p=0.0226). Moreover, a trend was shown towards early TNM stages in methylated tumors (p=0.209). Conclusions: WNT5A was more frequently methylated in early gastric carcinomas.