Alginates in Pharmaceutics and Biomedicine: Is the Future so Bright?
Alginates in Pharmaceutics and Biomedicine: Is the Future so Bright?
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DOI：
10.2174/1381612821666150820105639
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发表时间：
2015-01-01
影响因子：
3.1
通讯作者：
Ricci, Maurizio
中科院分区：
文献类型：
--
作者：
Giovagnoli, Stefano;Luca, Giovanni;Ricci, Maurizio
藻酸盐代表了用于制药和生物医学应用的最有吸引力的生物聚合物之一。藻酸盐作为临床使用的生物材料已经确立，尽管并非没有问题。在这里，我们提供了一个关键的审查在药物输送和其突出的作用，在细胞微囊化治疗疾病，如1型糖尿病的海藻酸盐研究的一些主要的最新进展。还将提供聚合物的基本性质的简要描述。基于我们的经验和贡献，以及在该领域的广泛研究，藻酸盐系统的物理化学和生物学特性与临床结果之间的相关性将被调查和讨论，以解决基于藻酸盐的递送策略的实际未来临床影响。
Alginate represents one of the most appealing biopolymers for pharmaceutical and biomedical applications. Alginate as a biomaterial for clinical use has been established, although not free from issues. Here we provide a critical review on some of the main recent advances in alginate research in drug delivery and its prominent role in cell microencapsulation for the treatment of diseases, such as type 1 diabetes mellitus. A brief description of the basic properties of the polymer will be provided as well. Based on our experience and contributions, as well as wide research in the field, the correlation between physicochemical and biological properties of alginate systems and clinical outcomes will be investigated and discussed to address the actual future clinical impact of alginate-based delivery strategies.