Microarray analysis of IFN-γ response genes in astrocytes
Microarray analysis of IFN-γ response genes in astrocytes
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DOI：
10.1016/j.jneuroim.2006.02.015
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发表时间：
2006-06-01
影响因子：
3.3
通讯作者：
Weiss, Louis M.
中科院分区：
文献类型：
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作者：
Halonen, Sandra K.;Woods, Tyson;Weiss, Louis M.
IFN-γ（IFN-γ）已被证明可以激活星形胶质细胞以获得免疫功能。在这项研究中，通过微阵列分析研究了IFN-γ对小鼠星形胶质细胞的影响。IFN-γ对星形胶质细胞转录组的激活作用显示出对参与适应性免疫、免疫应答启动和先天免疫的途径的优势。以前未知的星形胶质细胞基因表达包括p47 GTP酶和鸟嘌呤核苷酸结合蛋白（GBP）家族的成员。IFN-γ刺激的下调作用仅限于参与生长调节、细胞分化和细胞粘附的途径。该数据支持星形胶质细胞是脑中重要的免疫竞争细胞的观点，并表明星形胶质细胞可能在各种感染性疾病如弓形虫脑炎和具有免疫组分的神经系统疾病如阿尔茨海默病和自身免疫性疾病中具有重要作用。(c)2006 Elsevier B. V.保留所有权利。
IFN-gamma (IFN-gamma) has been shown to activate astrocytes to acquire immune functions. In this study the effect of IFN-gamma on murine astrocytes was investigated via microarray analysis. The activating effect of IFN-gamma on the astrocyte transcriptome showed predominance toward pathways involved in adaptive immunity, initiation of the immune response and innate immunity. Previously unknown astrocytic genes expressed included members of the p47 GTPases and guanine nucleotide binding protein (GBP) families. Down-regulatory effects of IFN-gamma stimulation were confined to pathways involved in growth regulation, cell differentiation and cell adhesion. This data supports the notion that astrocytes are an important immunocompetant cell in the brain and indicate that astrocytes may have a significant role in various infectious diseases such as Toxoplasmic Encephalitis and neurological diseases with an immunological component such as Alzheimer's and autoimmune disorders. (c) 2006 Elsevier B.V. All rights reserved.