Mouse Models of Autoimmune Diabetes: The Nonobese Diabetic (NOD) Mouse.
Mouse Models of Autoimmune Diabetes: The Nonobese Diabetic (NOD) Mouse.
复制标题
DOI：
10.1007/978-1-0716-0385-7_6
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Wong FS
中科院分区：
文献类型：
--
作者：
Chen D;Thayer TC;Wen L;Wong FS
现在有许多不同的1型糖尿病小鼠模型。最著名的是非肥胖糖尿病（NOD）小鼠，其具有对自身免疫性糖尿病的遗传易感性，其某些特征与人类1型糖尿病相似。小鼠也有其他自身免疫素质的倾向，包括自身免疫性甲状腺疾病和涎腺炎。此外，众所周知，环境因素会影响这些小鼠的发病率。虽然还有其他啮齿动物模型，包括许多转基因和基因敲除模型，以及表达人类蛋白质的模型，但这些模型在一段时间内都不会发展为自发性糖尿病，此时可以研究自然史。我们在这里集中在未经操作的NOD小鼠和讨论的特点，饲养和调查的小鼠，允许使用这些长期研究的小鼠在自身免疫性糖尿病的发病机制。
There are now a number of different mouse models for type 1 diabetes. The best known is the nonobese diabetic (NOD) mouse which has a genetic susceptibility to autoimmune diabetes with some features that are similar to human type 1 diabetes. The mice also have a propensity to other autoimmune diatheses, including autoimmune thyroid disease and sialadenitis. In addition, it is well known that environmental factors affect the incidence of disease in these mice. While there are other rodent models, including numerous transgenic and knockout models, as well as those that express human proteins, none of these develop spontaneous diabetes over a period of time, when the natural history can be studied. We focus here on the unmanipulated NOD mouse and discuss features of the husbandry and investigation of the mice that allow for use of these long-studied mice in the pathogenesis of an autoimmune type of diabetes.