Towards infrared photonic integrated circuits (PICs) in biochemical analysis: implementation of quantum cascade lasers (QCLs) in analysis of fluids
Towards infrared photonic integrated circuits (PICs) in biochemical analysis: implementation of quantum cascade lasers (QCLs) in analysis of fluids
复制标题
面向生化分析中的红外光子集成电路 (PIC)：在流体分析中实施量子级联激光器 (QCL)
DOI：
10.1117/12.2615367
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Roodenko, Katy
中科院分区：
文献类型：
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作者：
Daunis, Trey B.;Dussor, Jennifer C.;Le, Bach;Hodges, Kimari;Clark, Kevin P.;Robbins, Dennis I.;Roodenko, Katy
对用于流体的生化分析的手持式和/或现场级传感器的需求不断增长。这些系统可应用于废水处理行业中氮基化合物（如硝酸盐和氨）的监测;饮用水中的细菌检测;尿液或血液等生物流体的分析;以及许多其他领域。中红外（midIR）光谱是一个强大的工具，用于识别和定量的范围广泛的常见有机和无机化合物。虽然红外辐射在水中被强烈吸收，但该技术可通过利用衰减全反射（ATR）原理适用于流体分析。在这方面的贡献，我们强调了应用红外光谱在废水分析，以及在生物反应器中的代谢组学分析。我们讨论了液体生化分析所必需的IR信号稳定性要求，并提供了从FTIR过渡到QCL平台期间遇到的挑战的示例。总的来说，我们逐步努力的目标是最终将QCL光源，波导传感器和IR探测器集成到单个光子集成电路（PIC）上，用于国防部门以及广泛的消费市场。
There is a growing demand for hand-held and/or field-grade sensors for biochemical analysis of fluids. These systems have applications in monitoring of nitrogen-based compounds (such as nitrate and ammonia) in the wastewater treatment industry; bacterial detection in drinking water; analysis of biofluids, such as urine or blood; and in many other areas. Mid-infrared (midIR) spectroscopy is a powerful tool for identification and quantification of a wide range of common organic and inorganic compounds. Although IR radiation is strongly absorbed in water, this technology can be adapted for analysis of fluids by utilizing the principles of attenuated total reflection (ATR). In this contribution we highlight the application of IR spectroscopy in wastewater analysis as well as for metabolomic analysis in bioreactors. We discuss the requirements for IR signal stability that are necessary for biochemical analysis of fluids and provide examples of challenges encountered during transition from FTIR to a QCL-based platform. Overall, our stepwise efforts target eventual integration of a QCL light source, waveguide sensor, and IR detector onto a single photonic integrated circuit (PIC) for applications in the defense sector as well as for a broad consumer market.