Binuclear manganese-iron complexes containing ferrocenyl thiosemicarbazones: biological activity and carbon monoxide-releasing properties.
Binuclear manganese-iron complexes containing ferrocenyl thiosemicarbazones: biological activity and carbon monoxide-releasing properties.
复制标题
含有二茂铁基缩氨基硫脲的双核锰铁络合物：生物活性和一氧化碳释放特性。
DOI：
10.1016/j.ica.2020.119548
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发表时间：
2020
影响因子：
2.8
通讯作者：
Shell, SM
中科院分区：
文献类型：
--
作者：
Beckford, FA;Lawrence, ML;Shell, SM
一氧化碳(CO)因其大剂量的毒性而闻名。CO对肌红蛋白和血红蛋白都有很高的亲和力，并将与这两种蛋白质的血红素基团结合。这种结合会减少生物体可获得的氧气量，最终会导致疲劳和头痛等症状。由于其毒性，一氧化碳曾被认为在生物体内没有任何功能，但经过详细的研究，人们发现在人类体内，一氧化碳是血红素加氧酶(HO)分解的副产物[2]。血红素加氧酶以HO-2、HO-3和HO-1的形式存在。HO-1形式是一种诱导形式，当涉及到损伤和压力时，它是非常重要的。在没有HO-1的情况下，CO的浓度比正常水平低得多，这可能导致重要的酶不能上调。一氧化碳的另一个重要特征是，它可以在某些失调的过度增殖细胞中表现出促凋亡作用，如癌细胞[4]。一氧化碳已被证明是一种有用的抗炎、抗微生物和细胞保护剂[5]。一旦观察到CO可以执行这些重要的功能，科学家们就开始寻找含有CO的分子，这些分子的释放将产生这些效应。这些研究导致了一氧化碳释放分子(球茎)[6]、[7]、[8]、[9]的发展。这一领域的研究表明，金属羰基化合物有很大的潜力成为CO释放分子。Ru和Mn是具有多种生物功能的金属[10]、[11]、[12]，这使它们成为球茎的主要模板。这些球茎可以根据几个因素不同地释放气体和/或做出不同的反应；其中一个因素是不同波长的光的照射。对CO的光致发射敏感的络合物通常被称为光CORM。然而，化合物[6]、[13]、[14]、[15]的CO排放还有其他机制。
Carbon monoxide (CO) is well known for its toxicity in large doses. CO has a high affinity for both myoglobin and hemoglobin and will bind to the heme group of both of these proteins. This binding will reduce the amount of oxygen available to the organism which can ultimately lead to symptoms such as fatigue and headaches [1]. Because of its toxicity, CO was once thought to have no function in living organisms, but upon detailed study, it was found that CO is produced within humans as a byproduct of heme breakdown by heme oxygenase (HO)[2]. Heme oxygenase exists in the forms HO-2, HO-3, and HO-1. The HO-1 form, an inducible form, is very important when it comes to injury and stress. In the absence of HO-1, the concentrations of CO are much lower than normal, and this can result in important enzymes not being up-regulated. The negative side effects to this include blood clotting, slow healing, and poor resistance to infection [3].Another important characteristic of carbon monoxide is that it can exhibit proapoptotic effects in some dysregulated hyperproliferative cells such as cancer cells [4]. Carbon monoxide has been shown to be useful as an anti-inflammatory, anti-microbial, and cytoprotective agent [5]. Once it was observed that CO could perform these important functions, scientists went in search of molecules that contained CO, the release of which would produce these effects. These searches led to the development of carbon monoxide-releasing molecules (CORMs)[6],[7],[8],[9]. The research done in this field has shown that metal carbonyls have great potential to be CO-releasing molecules. Ruthenium and manganese are among the metals that have the ability to serve multiple biological functions [10],[11],[12], which makes them prime templates for CORMs. These CORMs can release the gas differently and/or react differently depending on several factors; one factor is irradiation by light of different wavelengths. Complexes that are susceptible to photoemission of CO are generally referred to as photoCORMs. However, there are other mechanisms for CO emission from compounds [6],[13],[14],[15].