Changes in Stereotypical Behavior Following Chlorpromazine Termination: Polypharmcy Effects on Response Class Membership.
Changes in Stereotypical Behavior Following Chlorpromazine Termination: Polypharmcy Effects on Response Class Membership.
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DOI：
10.1007/s41252-020-00158-7
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发表时间：
2020-09
影响因子：
--
通讯作者：
Kennedy CH
中科院分区：
文献类型：
--
作者：
Valdovinos MG;Aguilar M;Piersma D;Wilkinson A;Kennedy CH
关于影响陈规定型行为发生的可能的生物和环境相互作用的资料很少。特别是，关于精神药物的使用对被诊断患有智力残疾和自闭症谱系障碍等发育障碍的个体的刻板表现的影响的研究有限。我们研究了一名患有自闭症谱系障碍和智力残疾的男性的刻板印象，为期2年。刻板行为的地形图包括绕圈行走、头部敲击、手臂投掷和物体刻板。每周观察这些行为，同时参与者每天接受25 mg氯丙嗪，1.5 mg劳拉西泮和2，500 mg双丙戊酸钠。在第75周，停用氯丙嗪，同时维持其他药物和剂量。我们观察到，在统计学上显着减少走圈，但在其他地形的刻板印象没有变化。结果表明，粗运动活动受到氯丙嗪停药的不同影响，也表明多巴胺受体结合的改变可能选择性地影响了刻板反应的变化。
A paucity of information exists relating to the possible biological and environmental interactions influencing the occurrence of stereotypical behavior. In particular, there is limited research on the effects of psychotropic medication use on stereotypy presentation in individuals diagnosed with developmental disabilities such as intellectual disability and autism spectrum disorder. We studied the stereotypy of a man with autism spectrum disorder and intellectual disability across 2 years. The topographies of stereotypical behavior included walking in circles, head tapping, arm flinging, and object stereotypy. These behaviors were observed weekly while the participant received daily dosages of 25 mg of chlorpromazine, 1.5 mg of lorazepam, and 2,500 mg of divalproex. At Week 75, chlorpromazine was discontinued while the other drugs and dosages were maintained. We observed a statistically significant decrease in walking in circles, but no changes in the other topographies of stereotypy. The results suggest that the gross motor activity was differentially affected by the chlorpromazine discontinuation and also suggests that alterations in dopamine receptor binding may have selectively influenced changes in stereotypical responding.
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DOI：
10.1111/j.1365-2788.2012.01631.x
发表时间：
2014-01-01
影响因子：
3.6
作者：
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DOI：
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影响因子：
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DOI：
10.3174/ajnr.a4547
发表时间：
2016-03
期刊：
AJNR. American journal of neuroradiology
影响因子：
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作者：
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影响因子：
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作者：
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