Astrovirus induces diarrhea in the absence of inflammation and cell death
Astrovirus induces diarrhea in the absence of inflammation and cell death
复制标题
DOI：
10.1128/jvi.77.21.11798-11808.2003
复制
发表时间：
2003-11-01
影响因子：
5.4
通讯作者：
Schultz-Cherry, S
中科院分区：
文献类型：
--
作者：
Koci, MD;Moser, LA;Schultz-Cherry, S
星状病毒是全球婴儿病毒性胃肠炎的主要原因。关于星状病毒引起腹泻的机制知之甚少。其中一个原因是缺乏小动物模型。最近，我们从患有新出现的传染病家禽肠炎死亡综合征的火鸡中分离到一种新的星状病毒株（TAStV-2）。在本研究中，我们证明了TAStV-2导致生长抑制，胸腺大小减少，并在感染火鸡肠道感染。感染性TAStV-2可以从多种组织中回收，包括血液，这表明在感染期间存在病毒血症阶段。尽管有严重的腹泻，但肠道的组织病理学变化轻微，令人惊讶的是没有炎症。这可能是由于星状病毒感染期间强效免疫抑制细胞因子转化生长因子β的激活增加所致。这些研究表明，火鸡将是一个有用的小动物模型，研究星状病毒的发病机制和免疫。
Astroviruses are a leading cause of infantile viral gastroenteritis worldwide. Very little is known about the mechanisms of astrovirus-induced diarrhea. One reason for this is the lack of a small-animal model. Recently, we isolated a novel strain of astrovirus (TAstV-2) from turkeys with the emerging infectious disease poult enteritis mortality syndrome. In the present studies, we demonstrate that TAstV-2 causes growth depression, decreased thymus size, and enteric infection in infected turkeys. Infectious TAstV-2 can be recovered from multiple tissues, including the blood, suggesting that there is a viremic stage during infection. In spite of the severe diarrhea, histopathologic changes in the intestine were mild and there was a surprising lack of inflammation. This may be due to the increased activation of the potent immunosuppressive cytokine transforming growth factor beta during astrovirus infection. These studies suggest that the turkey will be a useful small-animal model with which to study astrovirus pathogenesis and immunity.