MORTALITY AND APNEA INDEX IN OBSTRUCTIVE SLEEP-APNEA - EXPERIENCE IN 385 MALE-PATIENTS
MORTALITY AND APNEA INDEX IN OBSTRUCTIVE SLEEP-APNEA - EXPERIENCE IN 385 MALE-PATIENTS
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DOI：
10.1378/chest.94.1.9
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发表时间：
1988-07-01
期刊：
影响因子：
9.6
通讯作者：
ROTH, T
中科院分区：
文献类型：
--
作者：
HE, J;KRYGER, MH;ROTH, T
虽然阻塞性睡眠呼吸暂停（OSA）已经详细研究了十多年，但这种疾病的死亡率尚不清楚。我们计算了385例男性OSA患者的累积生存率。我们发现，呼吸暂停指数（AI）> 20的患者的死亡率比AI =<20的患者高得多。累积8年生存概率为0.96 ± 0.96。0.02（SE）对于AI =<20 vs. 63. ±. 0.17对于AI> 20（p <.05）。与AI相关的死亡率差异在50岁以下的患者中尤其如此，因为其他原因导致的死亡并不常见。气管切开或经鼻CPAP治疗的患者无死亡。悬雍垂腭咽成形术（UPPP）治疗的患者中有8例死亡，UPPP单独治疗组的累积生存率与呼吸暂停指数大于20的未治疗OSA患者的生存曲线没有差异。我们的结论是，阻塞性睡眠呼吸暂停患者的呼吸暂停指数大于20有更大的死亡率比那些低于20和UPPP患者治疗后重新研究。如果发现后者患者的AI没有明显改善，则应通过鼻CPAP或气管切开术进行治疗。
Although obstructive sleep apnea (OSA) has been studied in detail for over a decade, the mortality of this disorder is unclear. We calculated cumulative survival in 385 male OSA patients. We found that those with an apnea index (AI) > 20 had a much greater mortality than those with AI = < 20. The probability of cumulative eight-year survival was .96 .+-. 0.02 (SE) for AI = < 20 vs. 63 .+-. 0.17 for AI > 20 (p < .05). This difference in mortality related to AI was particularly true in the patients less than 50 years of age in whom mortality from other causes is not common. None of the patients treated with tracheostomy or nasal CPAP died. Eight of the patients treated with uvulopalatopharyngoplasty (UPPP) died and the cumulative survival of the UPPP-alone treated group was not different from the survival curve of untreated OSA patients with an apnea index of greater than 20. We conclude that OSA patients with an apnea index of greater than 20 have a greater mortality than those below 20 and that UPPP patients be restudied after therapy. If the latter patients are found not to have marked amelioration of their AI, then they should be treated by nasal CPAP or tracheostomy.