Uniform biodegradable hydrogel microspheres fabricated by a surfactant-free electric-field-assisted method.
Uniform biodegradable hydrogel microspheres fabricated by a surfactant-free electric-field-assisted method.
复制标题
采用无表面活性剂电场辅助方法制备均匀的可生物降解水凝胶微球。
DOI：
10.1002/mabi.200700020
复制
发表时间：
2007
影响因子：
4.6
通讯作者：
K. Kim
中科院分区：
文献类型：
--
作者：
Y. B. Choy;Hyungsoo Choi;K. Kim
采用电场辅助精密粒子制备技术制备了尺寸可精确控制的均匀可生物降解水凝胶微球。通过给水凝胶液滴充电并允许库仑斥力将它们分开，防止了颗粒团聚。因此，无表面活性剂和无毒颗粒的制备成为可能，所得到的微球最适合于生物医学和食品相关的应用。由于尺寸的一致性，本发明的HMS可以作为一种方便而最准确的载体来控制给药和其他活性成分。
Uniform biodegradable hydrogel microspheres (HMS) with precisely controlled size have been fabricated using an electric-field-assisted precision particle fabrication technique. Particle agglomeration was prevented by charging the hydrogel drops and allowing Coulomb repulsion to separate them. As a result, surfactant-free and non-toxic particle fabrication was possible and the resulting microspheres were most suitable for biomedical and food-related applications. Due to the size uniformity, the present HMS may serve as a convenient yet most accurate vehicle for controlled delivery of therapeutic agents and other active ingredients.